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Therapeutic potential of nanoceria in regenerative medicine

Published online by Cambridge University Press:  13 November 2014

Soumen Das ,
Srinivasulu Chigurupati ,
Janet Dowding ,
Prabhakaran Munusamy ,
Donald R. Baer ,
James F. McGinnis ,
Mark P. Mattson ,
William Self  and
Sudipta Seal
Soumen Das
Affiliation:
Advanced Materials Processing Analysis Center, Nanoscience Technology Center, University of Central Florida, USA; soumen.das@ucf.edu
Srinivasulu Chigurupati
Affiliation:
Division of Neurotoxicology, US Food and Drug Administration, National Center for Toxicological Research, USA; srinivasulu.chigurupati@fda.hhs.gov
Janet Dowding
Affiliation:
Burnett School of Biomedical Science, University of Central Florida, USA; jdowding42q@gmail.com
Prabhakaran Munusamy
Affiliation:
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, USA; prabhakaran.munusamy@pnnl.gov
Donald R. Baer
Affiliation:
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, USA; don.baer@pnnl.gov
James F. McGinnis
Affiliation:
Department of Ophthalmology, University of Oklahoma Health Sciences Center, USA; James-McGinnis@ouhsc.edu
Mark P. Mattson
Affiliation:
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, USA; MattsonM@grc.nia.nih.gov
William Self
Affiliation:
Burnett School of Biomedical Science, University of Central Florida, USA; william.self@ucf.edu
Sudipta Seal
Affiliation:
Advanced Materials Processing and Analysis Center, Nanoscience and Technology Center, Mater. Sci. Eng., College of Medicine, University of Central Florida, USA; Sudipta.Seal@ucf.edu
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Abstract

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging, or trauma. Advancement of tissue engineering requires innovation in the field of three-dimensional scaffolding and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates that can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for an extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

Keywords

Cerare-earthsnanostructuresurface chemistrybiomedical
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 11: Biological Interactions of Oxide Nanoparticles: The Good and The Evil , November 2014 , pp. 976 - 983
Copyright
Copyright © Materials Research Society 2014 

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