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Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

  • Pengfei Duan (a1) (a2), Nehir Kandemir (a1), Jiajun Wang (a1) and Jinju Chen (a1)

Abstract

Hydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

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Copyright

Corresponding author

Corresponding author: E-mail: Jinju.chen@ncl.ac.uk

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These two authors contribute equally to this manuscript.

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References

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[1] Vlierberghe, S. V., Dubruel, P. and Schacht, E., Biomacromolecules 12(5), 1387 (2011).
[2] Lee, K. Y. and Mooney, D. J., Chem. Rev. 101(7), pp. 18691880 (2001).
[3] Kuo, C. K. and Ma, P. X., Biomaterials 22(6), 511 (2001).
[4] Martinsen, A., Skjåk-Bræk, G. and Smidsrød, O., Biotechnol. Bioeng. 33(1), 79 (1989).
[5] Klöck, G., Pfeffermann, A., Ryser, C., Gröhn, P., Kuttler, B., Hahn, H. J. and Zimmermann, U., Biomaterials 18(10), 707 (1997).
[6] Gombotz, W. R. and Wee, S. F., Adv. Drug Delivery Rev. 64, 194 (2012).
[7] Rowley, J. A., Madlambayan, G. and Mooney, D. J., Biomaterials 20(1), 45 (1999).
[8] Fratzl, P. (Ed.), Collagen: Structure and Mechanics, 1st ed (Springer, New York, 2008), p.113.
[9] Stagg, S. J., Pollot, B. E., Rathbone, C. R., Ong, A. and Guda, T., Interpenetrating Collagen-Fibrin Hydrogels for Skeletal Muscle Regeneration, WWW Document, (http://2015.biomaterials.org/sites/default/files/abstracts/608.pdf), [Accessed 22 04 2016].
[10] Chen, J., Irianto, J., Inamdar, S., Pravincumar, P., Lee, D. A., Bader, D. L. and Knight, M. M., Biophys. J. 103(6), 1188 (2012).
[11] Funami, T., Fang, Y., Noda, S., Ishihara, S., Nakauma, M., Draget, K. I., Nishinari, K. and Phillips, G. O., Food Hydrocoll. 23(7), 1746 (2009).
[12] Knapp, D. M., Barocas, V. H., Moon, A. G., Yoo, K., Petzold, L. R. and Tranquillo, R. T., J. Rheol. 41(5), 971 (1998).
[13] da Cunha, C. B. e. a., Biomaterials 35(32), 8927 (2014).

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Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

  • Pengfei Duan (a1) (a2), Nehir Kandemir (a1), Jiajun Wang (a1) and Jinju Chen (a1)

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