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Preparation and In Vitro Evaluation of Electrochemically-Aligned Collagen Matrix as a Dermal Substitute

Published online by Cambridge University Press:  05 April 2016

XingGuo Cheng ,
Nicole Edwards ,
Kelly Leung ,
David Zhang  and
Robert J. Christy
XingGuo Cheng*
Affiliation:
Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A.
Nicole Edwards
Affiliation:
Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A. University of Texas at San Antonio, One University Circle, TX 78249, U.S.A.
Kelly Leung
Affiliation:
Rochal Industries LLC, 12719 Cranes ML, San Antonio 78230, U.S.A.
David Zhang
Affiliation:
Rochal Industries LLC, 12719 Cranes ML, San Antonio 78230, U.S.A.
Robert J. Christy
Affiliation:
US Army Institute of Surgical Research, 3698 Chambers Pass Suite B., Fort Sam Houston, TX, 78234, U.S.A.
*
*(Email: xcheng@swri.org)
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Abstract

Due to injuries and disease, there is a great need for a robust, biocompatible, biodegradable, skin-like dermal substitute to repair and regenerate damaged or lost skin. A novel electrochemical process was used to fabricate planarly aligned, densely packed collagen-based sheet which closely mimics the major structure of collagen in skin. The collagen matrix was characterized by scanning electron microscopy (SEM), oxygen permeation, moisture vapor transmission rate (MVTR), and mechanical strength. The seeding and proliferation of adipose derived stem cells (ADSCs) on the matrix was also evaluated. The results indicate that electrochemically-aligned collagen matrix has good MVTR, superior oxygen permeability, and is robust and biocompatible. Thus, it will be evaluated in vivo in the near future as a dermal substitute material.

Keywords

biomaterialelectrochemical synthesisbiomimetic (assembly)
Type
Articles
Information
MRS Advances , Volume 1 , Issue 18: Biomaterials and Soft Materials , 2016 , pp. 1295 - 1300
Copyright
Copyright © Materials Research Society 2016 

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References

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