Skip to main content Accessibility help
×
Home

Patternable Rough Textured Gold Microwire for Neurochemical Sensing

  • Eva Mutunga (a1) and Pawan Tyagi (a2)

Abstract

Understanding spatial and temporal neuronal activities is crucial for finding the cure for brain related ailments and advancement of our knowledge about the brain itself. This paper discusses our recent finding of the patternable rough textured gold microwire for neurochemical sensing. We have successfully fabricated the ∼5 µm wide and ∼ 60 nm thick gold microwires based electrochemical sensor. We produced these microwires along the edge of lithographically patterned nickel thin film. A nickel thin film edge was shadowed by the photoresist overhang during electrochemical growth only to allow gold deposition along the edges. Our electrochemical growth conditions yielded very rough textured sensor. Rough textured biosensors are highly desirable for increasing surface/volume ratio for efficient electrochemical sensing. These rough-textured microwires were transformed into the functional neurochemical sensor to detect dopamine. Our voltammetry and chronoamperometry studies on rough textured microwires based sensor confirmed the successful detection of dopamine.

Copyright

Corresponding author

*(Email: ptyagi@udc.edu)

References

Hide All
1.Zachek, M.K., Hermans, A., Wightman, R.M., and Mccarty, G.S., Journal of Electroanalytical Chemistry 614, 113 (2008).
2.Garris, P.A., Ciolkowski, E.L., Pastore, P., and Wightman, R.M., Journal of Neuroscience 14 (10), 60846093 (1994).
3.Schultz, W., Nature Reviews Neuroscience 1, 199 (2000).
4.Venton, B.J. and Wightman, R.M., Analytical Chemistry 75 (19), 414A421A (2003).
5.Cooper, J.S., Bloom, F.E. and Roth, R.H., The biological basis of Neuropharmacology, 8th ed. (Oxford University Press, New York, 2002).
6.Phillips, P.E., Stuber, G.D., Heien, M.L., Wightman, R.M. and Carelli, R.M., Nature 422, 614 (2003).
7.Tyagi, P., Postetter, D., Saragnese, D.L., Randall, C.L., Mirski, M.A. and Gracias, D.H., Anal. Chem. 81, 9979 (2009).
8.Penner, R.M., Heben, M.J., Longin, T. L. and Lewis, N.S., Science 250 (4984), 11181121 (1990).
9.Arrigan, D. W. M., Chemical MicroAnalytics 129, 1157 (2004).
10.Xiang, C., Kung, S., Taggart, D.K., Yang, F., Thompson, M.A., Guell, A.G., Yang, Y. and Penner, R.M., ACS Nano 2 (9), 19391949 (2008).

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed