Skip to main content Accessibility help
×
Home

One-step Aqueous Synthesis of Zn-based Quantum Dots as Potential Generators of Reactive Oxygen Species

  • Julio A. Rivera (a1), Sonia J. Bailón-Ruiz (a2) and Oscar J. Perales-Perez (a3)

Abstract

The actual incorporation of dopant species into the ZnS Quantum Dots (QDs) host lattice will induce structural defects evidenced by a red shift in the corresponding exciton. The doping should create new intermediate energetic levels between the valence and conduction bands of the ZnS and affect the electron-hole recombination. These trap states would favour the energy transfer processes involved with the generation of cytotoxic radicals, so-called Reactive Oxygen Species, opening the possibility to apply these nanomaterials in cancer research. Any synthesis approach should consider the direct formation of the QDs in biocompatible medium. Accordingly, the present work addresses the microwave-assisted aqueous synthesis of pure and doped ZnS QDs. As-synthesized quantum dots were fully characterized on a structural, morphological and optical viewpoint. UV-Vis analyzes evidenced the excitonic peaks at approximately 310 nm, 314 nm and 315 nm for ZnS, Cu-ZnS and Mn-ZnS, respectively, Cu/Zn and Mn/Zn molar ratio was 0.05%. This indicates the actual incorporation of the dopant species into the host lattice. In addition, the Photoluminescence spectrum of non-doped ZnS nanoparticles showed a high emission peak that was red shifted when Mn2+ or Cu2+ were added during the synthesis process. The main emission peak of non-doped ZnS, Cu-doped ZnS and Mn-doped ZnS were observed at 438 nm, 487 nm and 521 nm, respectively. Forthcoming work will address the capacity of pure and Cu-, Mn-ZnS quantum dots to generate cytotoxic Reactive Oxygen Species for cancer treatment applications.

Copyright

Corresponding author

References

Hide All
[1]Rosiles-Perez, C. et al. , “Luminescent Cd1−xZnxS quantum dots synthesized by a nanoemulsion method, assisted by an ultrasonic probe,” J. Lumin., vol. 184, pp. 123129, 2017.
[2]Achakpa Ikyo, B., “Electron-Hole and Photon Recombination Processes in Quantum Well Semiconductor Lasers,” Am. J. Opt. Photonics, vol. 3, no. 5, p. 80, 2015.
[3]Bailón-Ruiz, S. and Perales-Pérez, O. J., “Generation of singlet oxygen by water-stable CdSe(S) and ZnSe(S) quantum dots,” Appl. Mater. Today, vol. 9, pp. 161166, 2017.
[4]Drummen, G., Drummen, , and G. P.C., “Quantum Dots—From Synthesis to Applications in Biomedicine and Life Sciences,” Int. J. Mol. Sci., vol. 11, no. 1, pp. 154163, Jan. 2010.
[5]Dai, X. et al. , “Solution-processed, high-performance light-emitting diodes based on quantum dots,” Nature, vol. 515, p. 96, Oct. 2014.
[6]Bailón-Ruiz, S. J., “Processing of Zn-Based Quantum Dots as Potential Photo-Sensitizers for Nanomedicine Applications.,” 2013.
[7]Trachootham, D. et al. , “Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate,” Cancer Cell, vol. 10, no. 3, pp. 241252, 2006.
[8]Samia, A. C. S., Chen, X., and Burda, C., “Semiconductor Quantum Dots for Photodynamic Therapy,” J. Am. Chem. Soc., vol. 125, no. 51, pp. 1573615737, Dec. 2003.
[9]Bwatanglang, I. B. et al. , “Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy,” Int. J. Nanomedicine, vol. 11, pp. 413428, Jan. 2016.
[10]Xuan, T.-T., Liu, J.-Q., Xie, R.-J., Li, H.-L., and Sun, Z., “Microwave-Assisted Synthesis of CdS/ZnS:Cu Quantum Dots for White Light-Emitting Diodes with High Color Rendition,” Chem. Mater., vol. 27, no. 4, pp. 11871193, Feb. 2015.
[11]Blaškovičová, J. et al. , “Detection of ROS Generated by UV-C Irradiation of CdS Quantum Dots and their Effect on Damage to Chromosomal and Plasmid DNA,” Electroanalysis, vol. 30, no. 4, pp. 698704, Dec. 2017.
[12]Shi, J.-J., Gong, L., Zhang, Y.-H., Yang, P., and He, J., “Microwave-assisted sonochemical synthesis of Cu and Mn doped GSH–ZnS polypeptide quantum dots and their enhanced photoelectrochemical properties,” RSC Adv., vol. 6, no. 111, pp. 109386109393, 2016.
[13]Peng, W. Q., Cong, G. W., Qu, S. C., and Wang, Z. G., “Synthesis and photoluminescence of ZnS:Cu nanoparticles,” Opt. Mater. (Amst)., vol. 29, no. 2–3, pp. 313317, 2006.
[14]Nanoclusters, I., “OPTICAL CHARACTERIZATION OF ZINC SULPHIDE ( ZnS ).”
[15]Angelé-Martínez, C., Nguyen, K. V. T., Ameer, F. S., Anker, J. N., and Brumaghim, J. L., “Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy,” Nanotoxicology, vol. 11, no. 2, pp. 278288, Feb. 2017.
[16]Dubey, M., “SYNTHESIS , STRUCTURAL AND OPTICAL CHARACTERIZATION OF CdS NANOPARTICLES,” Lab Man. Phys. Chem., vol. 6, no. 1, pp. 5762, 2010.

Keywords

One-step Aqueous Synthesis of Zn-based Quantum Dots as Potential Generators of Reactive Oxygen Species

  • Julio A. Rivera (a1), Sonia J. Bailón-Ruiz (a2) and Oscar J. Perales-Perez (a3)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed