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Laboratory Design for High-Performance Electron Microscopy

  • Michael A. O'Keefe (a1), John H. Turner (a1), John A. Musante (a1), Crispin J.D. Hetherington (a2), A.G. Cullis (a3), Bridget Carragher (a4), Ron Jenkins (a4), Julie Milgrim (a4), Ronald A. Milligan (a4), Clinton S. Potter (a4), Lawrence F. Allard (a5), Douglas A. Blom (a5), Lynn Degenhardt (a5) and William H. Sides (a5)...

Extract

Since publication of the classic text on the electron microscope laboratory by Anderson, the proliferation of microscopes with field emission guns, imaging filters and hardware spherical aberration correctors (giving higher spatial and energy resolution) has resulted in the need to construct special laboratories. As resolutions iinprovel transmission electron microscopes (TEMs) and scanning transmission electron microscopes (STEMs) become more sensitive to ambient conditions. State-of-the-art electron microscopes require state-of-the-art environments, and this means careful design and implementation of microscope sites, from the microscope room to the building that surrounds it. Laboratories have been constructed to house high-sensitive instruments with resolutions ranging down to sub-Angstrom levels; we present the various design philosophies used for some of these laboratories and our experiences with them. Four facilities are described: the National Center for Electron Microscopy OAM Laboratory at LBNL; the FEGTEM Facility at the University of Sheffield; the Center for Integrative Molecular Biosciences at TSRI; and the Advanced Microscopy Laboratory at ORNL.

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References

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1.“Design of the Electron Microscope Laboratory”, Anderson, R.H., Volume 4 of Practical Methods in Electron Microscopy, edited by Glauert, A.M., North-Holland, Amsterdam, 1975.
2.“Design and Implementation of a Site for a One-Ångström TEM” Turner, John H., O'Keefe, Michael A. and Mueller, Robert, in 55th Ann. Proc. MSA, Cleveland, Ohio (1997) 11771178.
3.“Installing and operating FEGTEMs” Hetherington, C.J., Cullis, A.G., Walker, S., Turner, J., Nelson, E.C., and O'Keete, M.A., Mat. Res. Soc. Symp. Proc. 523 (1998), ed, by Hayzelden, C., Hetherington, C.J.D., and Ross, F., 171-176.
4.“Design and Construction of a Suite for Molecular TEM” Potter, C.S., Carragher, B., Jenkins, R., Milgrim, J. and Milligan, R.A., Microscopy & Microanalysis 9, supplement 2 (2003) 950951.
5.“Electron Holography Lab Pushes Resolution Limit”, March Issues and Events, Physics Today, March 2001, http://physicstoday.org/pt/vol-54/iss-3/p24.html
7.At LBNL we specified sound absorbent on all four walls for maximum damping of acoustic noise generated in the instrument room. At a weekly meeting we found that they were installing it only on two walls because their acoustic expert had told them that any more would “make the room too dead to be comfortable”.
8.“The Triebenberg laboratory — designed for highest resolution election microscopy and holography”, Lichte, Hannes, Schulze, Dietrich, Lehmann, Michael, Just, Holger, Erabi, Taher, Fuerst, Peter, Goebel, Jaqueline, Hasenpusch, Andreas and Dietz, Peter (2001) Microscopy & Microanalysis 7, supplement 2,894-895.
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Microscopy Today
  • ISSN: 1551-9295
  • EISSN: 2150-3583
  • URL: /core/journals/microscopy-today
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