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Tissue Compatibility of Silicon Microfabricated Probes Inserted into the Brain
Published online by Cambridge University Press: 02 July 2020
Extract
The application of nano- and microfabricated devices based on silicon electronics technology is an emerging interdisciplinary area combining engineering and biology. The placement of electrically active probes in damaged or diseased tissues of the central nervous system could have enormous impact on the health and quality of life of large numbers of individuals by restoring lost function, or by treating or controlling disease states. Such probes have been fabricated at a high level of engineering sophistication. Unfortunately, when inserted into the brain a tissue reaction is initiated forming a scar that surrounds and electrically isolates the probe within a few weeks. This reaction is thought to primarily involve glial cells, and is undoubtedly dominated by the bulk surface of the probes which have a silicon oxide layer on top of single crystal silicon.
Model probes (Fig. 1) were microfabricated by photolithography with a 1×1mm tab used for gripping and inserting probes.
- Type
- Shared Resources: Access to Critical Instrumentation
- Information
- Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 289 - 290
- Copyright
- Copyright © Microscopy Society of America 1997
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