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Structural Studies of Coronavirus Fusion Proteins

Published online by Cambridge University Press:  05 August 2019

Alexandra C. Walls
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
M. Alejandra Tortorici
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. Institut Pasteur, Unité de Virologie Structurale, Paris 75015, France.
Xiaoli Xiong
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Joost Snijder
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Brandon Frenz
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Berend-Jan Bosch
Affiliation:
Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Frank DiMaio
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Davide Corti
Affiliation:
Humabs Biomed SA, Vir Biotechnology, 6500 Bellinzona, Switzerland.
Félix A. Rey
Affiliation:
Institut Pasteur, Unité de Virologie Structurale, Paris 75015, France.
David Veesler*
Affiliation:
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
*
*Corresponding author: dveesler@uw.edu

Abstract

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Type
3D Structures: from Macromolecular Assemblies to Whole Cells (3DEM FIG)
Copyright
Copyright © Microscopy Society of America 2019 

References

[1]Su, S, et al. (2016) Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends Microbiol 24(6):490-502.Google Scholar
[2]Bosch, BJ, van der Zee, R, de Haan, CA, & Rottier, PJ (2003) The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. Journal of virology 77(16):8801-8811.Google Scholar
[3]Walls, AC, et al. (2016) Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature 531(7592):114-117.Google Scholar
[4]Walls, AC, et al. (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proceedings of the National Academy of Sciences 114(42):11157-11162.Google Scholar
[5]Walls, AC, et al. (2016) Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy. Nature structural & molecular biology 23(10):899-905.Google Scholar
[6]Walls, AC, et al. (2019) Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. Cell 176(5):1026-1039 e1015.Google Scholar
[7]Xiong, X, et al. (2017) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. Journal of virology.Google Scholar