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Modeling Protein Structure in Macromolecular Assemblies at Near Atomic Resolutions

Published online by Cambridge University Press:  23 September 2015

Matthew L. Baker ,
Muyuan Chen ,
Philip R. Baldwin ,
Steven J. Ludtke  and
Wah Chiu
Matthew L. Baker
Affiliation:
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TXUSA
Muyuan Chen
Affiliation:
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TXUSA Program in Structural and Computational Biology, Baylor College of Medicine, Houston, TXUSA
Philip R. Baldwin
Affiliation:
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TXUSA
Steven J. Ludtke
Affiliation:
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TXUSA
Wah Chiu
Affiliation:
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TXUSA

Abstract

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Type
Abstract
Information
Microscopy and Microanalysis , Volume 21 , Supplement S3: Proceedings of Microscopy & Microanalysis 2015 , August 2015 , pp. 541 - 542
Copyright
Copyright © Microscopy Society of America 2015 

References

[1] Baker, ML, Zhang, J, Ludtke, SJ & Chiu, W. Cryo-EM of macromolecular assemblies at near-atomic resolution. Nat Protoc (2010). Sep;5(10), 1697–1708. PMCID: PMC3107675.CrossRefGoogle ScholarPubMed
[2] Baker, MR, Rees, I, Ludtke, SJ, Chiu, W & Baker, ML. Constructing and validating initial Ca models from subnanometer resolution density maps with pathwalking. Structure. 2012 Mar 7;20(3), 450–463. PMCID: PMC3307788.CrossRefGoogle Scholar
[3] Baker, ML, Baker, MR, Hryc, CF, Ju, T & Chiu, W. Gorgon and pathwalking: macromolecular modeling tools for subnanometer resolution density maps. Biopolymers. 2012 Sep;97(9), 655–668. PMCID: PMC3899894.CrossRefGoogle ScholarPubMed
[4] Wang, Z, Hryc, CF, Bammes, B, Afonine, PV, Jakana, J, Chen, DH, Liu, X, Baker, ML, Kao, C, Ludtke, SJ, Schmid, MF, Adams, PD & Chiu, W. An atomic model of brome mosaic virus using direct electron detection and real-space optimization. Nat Commun. 2014 Sep 4;5, 4808. PMCID: PMC4155512.CrossRefGoogle ScholarPubMed
[5] This work was supported by grants from the National Institutes of Health (P41GM103832, R01GM079429, R21GM100229), and National Science Foundation (DBI-1356306).Google Scholar