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Effect of Gasohol on The Rat Liver

Published online by Cambridge University Press:  02 July 2020

B.A. MacDuff ,
A. Singh  and
I. Chu
B.A. MacDuff
Affiliation:
Atlantic Veterinary College, Charlottetown, PE, CanadaClA 4P3
A. Singh
Affiliation:
Atlantic Veterinary College, Charlottetown, PE, CanadaClA 4P3
I. Chu
Affiliation:
Environmental Health Directorate, Health Protection Branch, Tunney ' s Pasture, Ottawa, ON, CanadaKlA 0L2
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Extract

Although there are a variety of gasoline ethanol mixtures proposed as neat fuels (ethanol 85% + gasoline 15% = E85; E95) for automobiles, gasohol (gasoline 90% + ethanol 10%) is presently used as a fuel in the United States. The adverse effects, if any, of gasohol ingestion are unknown; effects on the liver of rats administered gasohol are examined in this study.

Twenty-four female Sprague-Dawley rats received daily, via gavage, one of the three concentrations of gasohol for 28 days; LD50/20, LD50/100 and LD50/1000, where LD50 = 1.5g ethanol / kg body weight (bw) and 14g gasoline / kg bw. The LD50 was based on that of gasoline, which was obtained from literature value.1 The amount of ethanol added to stock gasohol was only 1/10 its LD50, required to maintain the gasoline ethanol proportion of 9:1. Gasohol was administered in corn oil with total volume 10 ml. Animals that received only corn oil served as controls.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 49 - 50
Copyright
Copyright © Microscopy Society of America 1997

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References

1Weaver, N.K., Ann. N. Y. Acad. Sci. 534(1988)441.10.1111/j.1749-6632.1988.tb30133.xCrossRefGoogle Scholar
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