Hostname: page-component-848d4c4894-v5vhk Total loading time: 0 Render date: 2024-06-24T04:59:27.714Z Has data issue: false hasContentIssue false
  • English
  • Français

Angiogenesis in Human Gastrointestinal Tumors: An Immunohistochemical and Immuno-Electron Microscopy Study

Published online by Cambridge University Press:  02 July 2020

P. Tonino ,
H.J. Finol ,
C. Hidalgo  and
L. Sosa
P. Tonino
Affiliation:
Center for Electron Microscopy, Faculty of Sciences, Central University of Venezuela, 47114, Caracas, 1041-A, Venezuela.
H.J. Finol
Affiliation:
Center for Electron Microscopy, Faculty of Sciences, Central University of Venezuela, 47114, Caracas, 1041-A, Venezuela.
C. Hidalgo
Affiliation:
Department of Structural Biology, IVIC, 21827, Caracas, 1020-A, Venezuela.
L. Sosa
Affiliation:
Department of Histology, Faculty of Medicine, Central University of Venezuela
Get access

Extract

Angiogenesis, the process of new blood vessels formation, is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of pronostic value in several types of malignancies, because it indicates a tumor's capacity for inducing angiogenesis. However, scarce data are available on angiogenesis in gastrointestinal tumors. Our previous work has revealed that gastrointestinal adenocarcinomas (GADC) vessels are anatomically heterogeneous structures. Additionally, it has been suggested that tumor-induced neovascularization in human carcinomas does not simply mean proliferation of capillaries, but it is also associated with certain functional changes in the vascular endothelial cells. Factor VTlI/von Willebrand factor (vWF) has been widely used for the demonstration of vascular endothelial cells as a representative marker. The aims of the present study were a) to determine whether the vascular density in GADC can be correlated to tumor aggressivness and provide prognostic information, and b) to clarify the ultrastructural immunolocalization of vWF in microvessels in the stroma of these tumors.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 576 - 577
Copyright
Copyright © Microscopy Society of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References:

1.Bossi, P. et al., Cancer Res. 55(1995)5049.Google Scholar
2.Pritchard, A.J. et al., Br. J. Cancer 71(1995)1081.CrossRefGoogle Scholar
3.Tonino, P. et al., VIEMC, Venezuela (1999).Google Scholar
4.Ohtani, H. and Nagura, H.. Virchows Arch. A Pathol. Anat., 417(1990)29.CrossRefGoogle Scholar
5.Ohtani, H. and Sasano, N.. J. Electron Microsc, 36(1987)204.Google Scholar
6.Weidner, N.. Sent. Diag. Pathol. 10(1993)302.Google Scholar
7. This research was supported by a grant from CDCH of UCV (Nr 03-26-362/99).Google Scholar