Skip to main content Accessibility help

Cadmium accumulation, distribution and metabolism in the gastropod Littorina littorea: the role of metal-binding proteins

  • W. J. Langston (a1) and Mingjiang Zhou (a1)


Cadmium, and its compounds, has been placed on the blacklists of most international pollution conventions by virtue of its toxicity, potential for bioaccumulation and persistence (Taylor, 1983).

The ability of many marine molluscs, and in particular gastropods, to accumulate Cd to a high degree in apparently unregulated fashion has led to their frequent use in monitoring programmes. Thus Cd levels in the winkle, Littorina littorea (L.) closely reflect gradients in environmental contamination (Bryan et al. 1983), demonstrating the excellent ‘indicator’ properties of this group.



Hide All
Brouwer, M. & Engel, D. W., 1982. Stoichiometry and functional consequences of Hg(II) and Cd(II) binding to arthropod hemocyanins. In Physiological Mechanisms of Marine Pollutant Toxicity (ed. Vernberg, W. al.), pp. 289310. New York: Academic Press.
Brouwer, M., Brouwer-Hoexum, T. & Engel, D. W., 1984. Cadmium accumulation by the blue crab, Callinectes sapidus: involvement of haemocyanin and characterization of cadmiumbinding proteins. Marine Environmental Research, 14, 7188.
Brown, D. A., Gosset, R. W., Hershelman, P., Schaefer, H. A., Jenkins, K. D. & Perkins, E. M., 1983. Bioaccumulation and detoxification of contaminants in marine organisms from southern California coastal waters. In Waste Disposal in the Oceans (ed. Soule, D. F. and Walsh, D.), pp. 171193. Boulder, Colorado: Westview Press.
Bryan, G. W., 1964. Zinc regulation in the lobster Homarus vulgaris. I. Tissue zinc and copper concentrations. Journal of the Marine Biological Association of the United Kingdom, 44, 549563.
Bryan, G. W., Langston, W. J., Hummerstone, L. G., Burt, G. R. & Ho, Y. B., 1983. An assessment of the gastropod, Littorina littorea, as an indicator of heavy-metal contamination in United Kingdom estuaries. Journal of the Marine Biological Association of the United Kingdom, 63, 327345.
Carpene, E. & George, S. G., 1981. Absorption of cadmium by gills of Mytilus edulis (L.). Molecular Physiology, 1, 2324.
Evtushenko, Z. S., Belcheva, N. N. & Lukyanova, O. N., 1986. Cadmium accumulation in organs of the scallop Mizuhopecten yessoensis. II. Subcellular distribution of metals and metal-binding proteins. Comparative Biochemistry and Physiology, 83C, 377383.
Fowler, S. W. & Benayoun, G., 1974. Experimental studies on cadmium flux through marine biota. In Comparative Studies of Food and Environmental Contamination, pp. 159174. Vienna. [IAEA report SM-175/10.]
Frazier, J. M. & George, S. G., 1983. Cadmium kinetics in oysters-a comparative study of Crassostrea gigas and Ostrea edulis. Marine Biology, 76, 5561.
Frazier, J. M., George, S. G., Overnell, J., Coombs, T. L. & Kagi, J., 1985. Characterisation of two molecular weight classes of cadmium binding proteins from the mussel, Mytilus edulis (L.). Comparative Biochemistry and Physiology, 80C, 257262.
Jackim, E., Morrison, G. & Steele, R., 1977. Effects of environmental factors on radiocadmium uptake by four species of marine bivalves, Marine Biology, 40, 303308.
Langston, W. J. & Zhou, M., 1986. Evaluation of the significance of metal-binding proteins in the gastropod Littorina littorea. Marine Biology, 92, 505515.
Langston, W. J. & Zhou, M., 1987. Cadmium accumulation, distribution and elimination in the bivalve Macoma balthica: neither metallothionein nor metallothionein-like proteins are involved. Marine Environmental Research, 21, 225237.
Mason, A. Z. & Nott, J. A., 1980. The association of the blood vessels and the excretory epithelium in the kidney of Littorina littorea (L.) (Mollusca, Gastropoda). Marine Biology Letters, 1, 355365.
Morse, M. P., Meyhöfer, E. & Robinson, W. E., 1985. Accumulation of 109cadmium in extracellular granules in the kidney of the bivalve mollusc Mercenaria mercenaria (L.). Marine Environmental Research, 17, 172175.
Noel-Lambot, F., Bouquegneau, J. M., Frankenne, F. & Disteche, A., 1978. Le rôle des métallothioneines dans le stockage des métaux lourds chez les animaux marins. Revue internationale d'océanographie médicate, 49, 1320.
Nolan, C. V. & Duke, E. J., 1983 a. Cadmium accumulation and toxicity in Mytilus edulis. Involvement of metallothioneins and heavy molecular weight protein. Aquatic Toxicology, 4, 153163.
Nolan, C. V. & Duke, E. J., 1983 b. Cadmium binding proteins in Mytilus edulis. Relation to mode of administration and significance in tissue retention of cadmium. Chemosphere, 12, 6574.
Ray, S., 1984. Bioaccumulation of cadmium in marine organisms. Experientia, 40, 1423.
Ray, S., McLeese, D. W., Waiwood, B. A. & Peczzack, D., 1980. The disposition of cadmium and zinc in Pandalus montagui. Archives of Environmental Contamination and Toxicology, 9, 675681.
Robinson, W. E. & Ryan, D. K., 1986. Metal interactions within the kidney, gill, and digestive gland of the hard clam, Mercenaria mercenaria, following laboratory exposure to cadmium. Archives of Environmental Contamination and Toxicology, 15, 2330.
Scholz, N., 1980. Accumulation, loss and molecular distribution of cadmium in Mytilus edulis. Helgoländer wissenschaftliche Meeresuntersuchungen, 33, 6878.
Scott, B. J. & Bradwell, A. R., 1983. Identification of the serum binding proteins for iron, zinc, cadmium, nickel, calcium. Clinical Chemistry, 29, 629633.
Taylor, D., 1983. The significance of the accumulation of cadmium by aquatic organisms. Ecotoxicology and Environmental Safety, 1, 3342.
Vasak, M. & Kagi, J. H. R., 1983. Spectroscopic properties of metallothionein. In Metal Ions in Biological Systems, vol. 15 (ed. Sigel, H.), pp. 213273. New York: Dekker.
Zaroogian, G. E., 1979. Studies on the depuration of cadmium and copper by the American oyster, Crassostrea virginica. Bulletin of Environmental Contamination and Toxicology, 23, 117122.


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed