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Angiotensin I-converting enzyme-like activity in a cephalochordate

Published online by Cambridge University Press:  08 January 2004

Christopher S. Cobb ,
John Rundle ,
Susan C. Frankling  and
J. Anne Brown
Christopher S. Cobb
Affiliation:
School of Biological and Chemical Sciences, Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
John Rundle
Affiliation:
The Marine Biological Association, The Laboratory, Citadel Hill, Plymouth, PL1 2PB, UK The Department of Biological Sciences, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK
Susan C. Frankling
Affiliation:
School of Biological and Chemical Sciences, Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
J. Anne Brown
Affiliation:
School of Biological and Chemical Sciences, Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
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Abstract

The presence of angiotensin I-converting enzyme-like activity (ACELA) was investigated in whole body homogenates of Branchiostoma lanceolatum using a highly sensitive fluorimetric assay. The measured enzyme activity was inhibited by the two angiotensin converting enzyme inhibitors, captopril and enalapril, suggesting a biochemical pathway that could generate the angiotensins observed in the central nervous system of amphioxus.

Type
Research Article
Information
Journal of the Marine Biological Association of the United Kingdom , Volume 83 , Issue 6 , December 2003 , pp. 1307 - 1308
Copyright
2003 Marine Biological Association of the United Kingdom

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