Skip to main content Accessibility help
×
Home

Sustained attention is associated with left ventricular ejection fraction in older adults with heart disease

  • BETH A. JERSKEY (a1), RONALD A. COHEN (a1), ANGELA L. JEFFERSON (a2), KARIN F. HOTH (a1) (a3), ANDREANA P. HALEY (a1) (a4), JOHN J. GUNSTAD (a5), DANIEL E. FORMAN (a6), LAWRENCE H. SWEET (a1) and ATHENA POPPAS (a7)...

Abstract

Poor cardiac pumping efficiency has shown to lead to cognitive impairments in patients with cardiovascular disease (CVD). The current study examined the relationship between left ventricular ejection fraction and sustained attention and inhibitory processes measured by the Adaptive Rate Continuous Performance Task and the Go/No-go test. Participants were 67 older outpatients (age 68.5 ± 7.4) with a range of CVD. Associations between cognition and ejection fraction were examined via linear regression analysis. Results were consistent with the hypothesis that lower ejection fraction is significantly associated with decrements in sustained attention and vigilance. Overall, the results provide support for the hypothesis that a change in cardiac pumping leads to decrements in some aspects of attention; however, inhibitory processes are relatively spared. (JINS, 2009, 15, 137–141.)

Copyright

Corresponding author

*Correspondence and reprint requests to: Ronald A. Cohen, Miriam Hospital Neuropsychology Clinic, The CORO Building, 3rd Floor, One Hoppin Street, Providence, RI 02903. E-mail: rcohen@lifespan.org; beth_jerskey@brown.edu

References

Hide All
Adler, C.M., Sax, K.W., Holland, S.K., Schmithorst, V., Rosenberg, L., & Strakowski, S.M. (2001). Changes in neuronal activation with increasing attention demand in healthy volunteers: An fMRI study. Synapse, 42(4), 266272.
Alves, T.C., Rays, J., Fráguas, R. Jr., Wajngarten, M., Meneghetti, J.C., Prando, S., & Busatto, G.F. (2005). Localized cerebral blood flow reductions in patients with heart failure: A study using 99mTc-HMPAO SPECT. Journal of Neuroimaging, 15(2), 150156.
Ammermann, H., Kassubek, J., Lotze, M., Gut, E., Kaps, M., Schmidt, J., Rodden, F.A., & Grodd, W. (2007). MRI brain lesion patterns in patients in anoxia-induced vegetative state. Journal of the Neurological Sciences, 60(1-2), 6570.
Appelman, A.P., van der Graaf, Y., Vincken, K.L., Tiehuis, A.M., Witkamp, T.D., Mali, W.P., Geerlings, M.I., & SMART Study Group. (2008). Total cerebral blood flow, white matter lesions and brain atrophy: The SMART-MR study. Journal of Cerebral Blood Flow and Metabolism, 28(3), 633639.
Beck, A. & Steer, R. (1993). Manual for the Beck Depression Inventory. San Antonio, TX: Psychological Corporation.
Brickman, A.M., Habeck, C., Zarahn, E., Flynn, J., & Stern, Y. (2007). Structural MRI covariance patterns associated with normal aging and neuropsychological functioning. Neurobiology of Aging, 28(2), 284295.
Caine, D. & Watson, J.D. (2000). Neuropsychological and neuropathological sequelae of cerebral anoxia: A critical review. Journal of the International Neuropsychological Society, 6(1), 8699.
Cohen, R.A. & Gunstad, J. (2008, February). Adaptive Rate Continuous Performance Test: Standardization and validation. Poster presented at the 36th annual meeting of the International Neuropsychological Society, Waikoloa, Hawaii.
Cummings, J.L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50(8), 873880.
Degirmenci, B., Durak, H., Hazan, E., Karabay, O., Derebek, E., Yilmaz, M., Ozbilek, E., & Oto, O. (1998). The effect of coronary artery bypass surgery on brain perfusion. Journal of Nuclear Medicine, 39(4), 587591.
Enzinger, C., Fazekas, F., Ropele, S., & Schmidt, R. (2007). Progression of cerebral white matter lesions—Clinical and radiological considerations. Journal of Neurological Science, 257(1-2), 510.
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Futterman, L.G. & Lemberg, L. (2000). The Framingham Heart Study: A pivotal legacy of the last millennium. American Journal of Critical Care, 9(2), 147151.
Gehring, W.J. & Knight, R.T. (2000). Prefrontal-cingulate interactions in action monitoring. Nature Neuroscience, 3(5), 516520.
Jefferson, A.L., Poppas, A., Paul, R.H., & Cohen, R.A. (2006). Systemic hypoperfusion is associated with executive dysfunction in geriatric cardiac patients. Neurobiology of Aging, 28(3), 477483.
Kalaria, R.N. (2003). Vascular factors in Alzheimer’s disease. International Psychogeriatrics, 15(Suppl 1), 4752.
Landi, F., Onder, G., Cattel, C., Gambassi, G., Lattanzio, F., Cesari, M., Russo, A., Bernabei, R., & Silvernet-HC Study Group. (2001). Functional status and clinical correlates in cognitively impaired community-living older people. Journal of Geriatric Psychiatry and Neurology, 14(1), 2127.
Lang, R.M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Roman, M.J., Seward, J., Shanewise, J.S., Solomon, S.D., Spencer, K.T., Sutton, M.S., Stewart, W.J., Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, & European Association of Echocardiography. (2005). Recommendations for chamber quantification: A report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. Journal of the Society of American Echocardiography, 18, 14401463.
Lezak, M.D. (1995). Neuropsychological Assessment, 3rd Edition. New York: Oxford University Press.
Liu, T.T. & Brown, G.G. (2007). Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods. Journal of the International Neuropsychological Society, 13, 19.
Mattis, S. (1988). Dementia Rating Scale (DRS). Odessa, FL: Psychological Assessment Resources.
Moody, D.M., Bell, M.A., & Challa, V.R. (1990). Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: An anatomic study. American Journal of Neuroradiology, 11(3), 431439.
O’Sullivan, M., Lythgoe, D.J., Pereira, A.C., Summers, P.E., Jarosz, J.M., Williams, S.C., & Markus, H.S. (2002). Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology, 59(3), 321326.
Paul, R.H., Gunstad, J., Poppas, A., Tate, D.F., Foreman, D., Brickman, A.M., Jefferson, A.L., Hoth, K., & Cohen, R.A. (2005). Neuroimaging and cardiac correlates of cognitive function among patients with cardiac disease. Cerebrovascular Disease, 20, 129133.
Roine, R.O., Launes, J., Nikkinen, P., Lindroth, L., & Kaste, M. (1991). Regional cerebral blood flow after human cardiac arrest. A hexamethylpropyleneamine oxime single photon emission computed tomographic study. Archives of Neurology, 48(6), 625629.
Rosvold, H.E., Mirsky, A.F., Sarandon, I., Bransome, E.D., & Beck, L.H. (1956). A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343350.
Sarter, M., Givens, B., & Bruno, J.P. (2001). The cognitive neuroscience of sustained attention: Where top-down meets bottom-up. Brain Research Brain Research Reviews, 35(2), 146160.
Tao, J., Jin, Y.F., Yang, Z., Wang, L.C., Gao, X.R., Lui, L., & Ma, H. (2004). Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: Comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement. American Journal of Hypertension, 17(8), 654659.
Toro, R., Fox, P.T., & Paus, T. (2008). Functional coactivation map of the human brain. Cerebral Cortex, 18(11), 25532559.

Keywords

Sustained attention is associated with left ventricular ejection fraction in older adults with heart disease

  • BETH A. JERSKEY (a1), RONALD A. COHEN (a1), ANGELA L. JEFFERSON (a2), KARIN F. HOTH (a1) (a3), ANDREANA P. HALEY (a1) (a4), JOHN J. GUNSTAD (a5), DANIEL E. FORMAN (a6), LAWRENCE H. SWEET (a1) and ATHENA POPPAS (a7)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed