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Structural Brain Correlations of Visuospatial and Visuoperceptual Tests in Parkinson’s Disease

  • Anna Isabel Garcia-Diaz (a1) (a2), Barbara Segura (a1) (a2), Hugo Cesar Baggio (a1) (a2), Maria Jose Marti (a3) (a4) (a5), Francesc Valldeoriola (a3) (a4) (a5), Yaroslau Compta (a2) (a3) (a4) (a5), Nuria Bargallo (a2) (a3) (a6), Carme Uribe (a1) (a2), Anna Campabadal (a1) (a2) (a3), Alexandra Abos (a1) (a2) and Carme Junque (a1) (a2) (a3) (a4)...

Abstract

Background: Diagnosis of mild cognitive impairment in Parkinson’s disease (PD) is relevant because it is a marker for evolution to dementia. However, the selection of suitable tests to evaluate separate cognitive domains in mild cognitive impairment related to PD remains an open question. The current work aims to investigate the neuroanatomical correlates of several visuospatial/visuoperceptual tests using the same sample and a multimodal MRI approach. Methods: The study included 36 PD patients and 20 healthy subjects matched for age, sex, and education. The visuospatial/visuoperceptual tests selected were: Pentagon Copying Test (PCT), Judgment of Line Orientation Test (JLOT), Visual Form Discrimination Test (VFDT), Facial Recognition Test (FRT), Symbol Digit Modalities Test (SMDT), and clock copying task (CLOX2). FreeSurfer was used to assess cortical thickness, and tract-based spatial statistics was used for fractional anisotropy analysis. Results: Lower performance in the PCT, JLOT, and SDMT was associated with extensive cortical thickness reductions in lateral parietal and temporal regions. VFDT and CLOX2 did not show this common pattern and correlated with more limited medial occipito-temporal and occipito-parietal regions. Performance in all visuospatial/visuoperceptual tests correlated with fractional anisotropy in the corpus callosum. Conclusions: Our findings show that JLOT, SDMT, and PCT, in addition to differentiating patients from controls, are suitable visuospatial/visuoperceptual tests to reflect cortical thinning in lateral temporo-parietal regions in PD patients. We did not observe the dissociation between dorsal and ventral streams that was expected according to the neuropsychological classification of visuospatial and visuoperceptual tests. (JINS, 2018, 24, 33–44)

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This is anOpenAccess article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Correspondence and reprint requests to: Carme Junqué, Department of Medicine, Faculty of Medicine and Health Science, University of Barcelona, Casanova 143 (08036) Barcelona, Spain. E-mail: cjunque@ub.edu

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