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Spatial memory deficits in patients after unilateral selective amygdalohippocampectomy

Published online by Cambridge University Press:  01 October 2004

ROY P.C. KESSELS ,
MARC P.H. HENDRIKS ,
JACOB SCHOUTEN ,
MARIEKE VAN ASSELEN  and
ALBERT POSTMA
ROY P.C. KESSELS
Affiliation:
Helmholtz Instituut, Utrecht University, The Netherlands Department of Neurology, University Medical Center Utrecht, The Netherlands
MARC P.H. HENDRIKS
Affiliation:
Nijmegen Institute of Cognition and Information, Radboud University Nijmegen, The Netherlands Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands
JACOB SCHOUTEN
Affiliation:
Helmholtz Instituut, Utrecht University, The Netherlands Hans Berger Clinic, Epilepsy Centre Breda, The Netherlands
MARIEKE VAN ASSELEN
Affiliation:
Helmholtz Instituut, Utrecht University, The Netherlands
ALBERT POSTMA
Affiliation:
Helmholtz Instituut, Utrecht University, The Netherlands
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Abstract

The present study investigated the differential involvement of the right and left hippocampus in various forms of spatial memory: spatial search, positional memory versus object–location binding, and coordinate versus categorical processing. Twenty-five epilepsy patients with selective amygdalohippocampectomy were examined using a sensitive computer paradigm to measure these spatial memory aspects. The patients' performance was compared to a group of thirty healthy controls. The results show that the left amygdalohippocampectomy group performed poorly on the ability to bind together object information to coordinate spatial locations. In turn, the right amygdalohippocampectomy group was impaired in coordinate positional memory. Both patient groups were unimpaired on the spatial search task. These findings are discussed focusing on the “binding device” hypothesis in combination with the cognitive map theory. (JINS, 2004, 10, 907–912.)

Keywords

Spatial memoryEpilepsyHippocampusMedial temporal lobeAmygdalohippocampectomy
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 6 , October 2004 , pp. 907 - 912
Copyright
© 2004 The International Neuropsychological Society

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