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Motivational Sensitivities Linked to Impulsive Motor Errors in Parkinson’s Disease

Published online by Cambridge University Press:  22 August 2017

Richard Laurent ,
Nelleke Corine van Wouwe ,
Maxim Turchan ,
Christopher Tolleson ,
Fenna Phibbs ,
Elise Bradley ,
Wery van den Wildenberg  and
Scott A. Wylie
Richard Laurent*
Affiliation:
Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Nelleke Corine van Wouwe
Affiliation:
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee
Maxim Turchan
Affiliation:
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee
Christopher Tolleson
Affiliation:
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee
Fenna Phibbs
Affiliation:
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee
Elise Bradley
Affiliation:
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee
Wery van den Wildenberg
Affiliation:
Amsterdam Brain and Cognition (ABC) and Psychology Department, University of Amsterdam, Amsterdam, The Netherlands
Scott A. Wylie
Affiliation:
Department of Neurosurgery, University of Louisville, Louisville, Kentucky
*
Correspondence and reprint requests to: Richard L. Laurent, 200 Hawkins Drive, 0120Z Roy Carver Pavilion, Department of Neurology-Neuropsychology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242. E-mail: richard-laurent@uiowa.edu
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Abstract

Objectives: We investigated how broad motivational tendencies are related to the expression and suppression of action impulses in Parkinson’s disease (PD). Methods: Sixty-nine participants with PD completed a Simon response conflict task and Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS) scales based on Gray’s (1987) reinforcement sensitivity theory. Analyses determined relationships between BIS, BAS, and the susceptibility to making impulsive action errors and the proficiency of inhibiting interference from action impulses. Results:BIS scores correlated positively with rates of impulsive action errors, indicating that participants endorsing low BIS tendencies were much more susceptible to acting on strong motor impulses. Analyses of subgroups with high versus low BIS scores confirmed this pattern and ruled out alternative explanations in terms of group differences in speed-accuracy tradeoffs. None of the scores on the BIS or BAS scales correlated with reactive inhibitory control. Conclusions: PD participants who endorse diminished predilection toward monitoring and avoiding aversive experiences (low BIS) show much greater difficulty restraining fast, impulsive motor errors. Establishing relationships between motivational sensitivities and cognitive control processes may have important implications for treatment strategies and positive health outcomes in participants with PD, particularly those at risk for falling and driving difficulties related to impulsive reactions. (JINS, 2018, 24, 128–138)

Keywords

InhibitionCognitionArousalRewardPunishmentIndividuality
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 24 , Issue 2 , February 2018 , pp. 128 - 138
Copyright
Copyright © The International Neuropsychological Society 2017 

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