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Major Depressive Disorder, Cognitive Symptoms, and Neuropsychological Performance among Ethnically Diverse HIV+ Men and Women

  • Robert P. Fellows (a1), Desiree A. Byrd (a1) and Susan Morgello (a1)


Major depressive disorder (MDD), cognitive symptoms, and mild cognitive deficits commonly occur in HIV-infected individuals, despite highly active antiretroviral therapies. In this study, we compared neuropsychological performance and cognitive symptoms of 191 HIV-infected participants. Results indicated that participants with a formal diagnosis of current MDD performed significantly worse than participants without MDD in all seven neuropsychological domains evaluated, with the largest effect sizes in information processing speed, learning, and memory. In addition, a brief assessment of cognitive symptoms, derived from a comprehensive neuromedical interview, correlated significantly with neurocognitive functioning. Participants with MDD reported more cognitive symptoms and showed greater neurocognitive deficits than participants without MDD. These findings indicate that HIV-infected adults with MDD have more cognitive symptoms and worse neuropsychological performance than HIV-infected individuals without MDD. The results of this study have important implications for the diagnosis of HIV-associated neurocognitive disorders (HAND). (JINS, 2013, 19, 1–10)


Corresponding author

Correspondence and reprint requests to: Robert P. Fellows, Department of Neurology, Box 1134 Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029. E-mail:


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Major Depressive Disorder, Cognitive Symptoms, and Neuropsychological Performance among Ethnically Diverse HIV+ Men and Women

  • Robert P. Fellows (a1), Desiree A. Byrd (a1) and Susan Morgello (a1)


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