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Hippocampal volume and retention in Alzheimer's disease

  • JOEL H. KRAMER (a1), NORBERT SCHUFF (a2), BRUCE R. REED (a3), DAN MUNGAS (a3), AN-TAO DU (a2), HOWARD J. ROSEN (a1), WILLIAM J. JAGUST (a3), BRUCE L. MILLER (a1), MICHAEL W. WEINER (a2) and HELENA C. CHUI (a4)...

Abstract

This study tested the hypothesis that the hippocampus has a relatively specific role in retaining information over delays. Thirty-seven subjects with probable Alzheimer's disease were evaluated with a verbal memory task and structural MRI. Cortical gray matter but not hippocampal volume predicted immediate free recall. In contrast, hippocampal volume was the best predictor of how well information was retained over a delay, even after controlling for levels of immediate recall. Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories. (JINS, 2004, 10, 639–643.)

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Corresponding author

Reprint requests to: Joel Kramer, Psy.D., University of California, San Francisco, Campus Box 0984-PAC, 401 Parnassus Avenue, San Francisco, CA 94143. E-mail: kramer@itsa.ucsf.edu

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Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
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