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Examining the effects of two factors on working memory maintenance of bound information in schizophrenia

Published online by Cambridge University Press:  01 July 2009

DAVID LUCK ,
LISA BUCHY ,
MARTIN LEPAGE  and
JEAN-MARIE DANION
DAVID LUCK*
Affiliation:
INSERM U.666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, Strasbourg Cedex, France
LISA BUCHY
Affiliation:
Brain Imaging Group, Douglas Institute Research Centre, Verdun, Quebec, Canada
MARTIN LEPAGE
Affiliation:
Brain Imaging Group, Douglas Institute Research Centre, Verdun, Quebec, Canada
JEAN-MARIE DANION
Affiliation:
INSERM U.666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, Strasbourg Cedex, France
*
*Correspondence and reprint requests to: Dr. David Luck, Brain Imaging Group, Douglas Institute Research Centre, McGill University, 6875 Boulevard LaSalle, Verdun, Quebec, Canada H4H 1R3. E-mail: david.luck@mail.mcgill.ca
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Abstract

Integrating information in space and time is a central feature of episodic memory. Although disturbance of the binding processes in episodic memory is well established in patients with schizophrenia, data on working memory (WM) remain discrepant. In a change detection procedure, two target displays of pairs of letters located in cells of grid were successively presented. Participants attempted to detect changes in binding information (i.e., recombination of studied features) or feature information (i.e., a novel letter and/or a novel spatial location). Recombinations consisted of features belonging to the same display (intradisplay) or different displays (interdisplays). Results showed that patients demonstrated overall lower performance, with no specific deficit for recognizing bound information or feature information. In addition, patients did not demonstrate deficits for interdisplay recombinations or intradisplay recombinations. Patients’ ability to remember temporal occurrence of stimuli was not affected. Together, these results suggest that in patients with schizophrenia, binding processes in WM are not specifically disturbed. (JINS, 2009, 15, 597–605.)

Keywords

AttentionBindingSpatialVerbalEpisodeInterference
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 4 , July 2009 , pp. 597 - 605
Copyright
Copyright © The International Neuropsychological Society 2009

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