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Assessment of neglect reveals dissociable behavioral but not neuroanatomical subtypes

Published online by Cambridge University Press:  26 February 2009

Regina McGlinchey-Berroth ,
David P. Bullis ,
William P. Milberg ,
Mieke Verfaellie ,
Michael Alexander  and
Mark D'Esposito
Regina McGlinchey-Berroth
Affiliation:
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Brockton/West Roxbury Division, West Roxbury, MA 02132 Department of Psychiatry, Harvard University Medical School, Boston, MA 02115 Memory Disorders Research Center, Boston University School of Medicine, Boston, MA 02115
David P. Bullis
Affiliation:
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Brockton/West Roxbury Division, West Roxbury, MA 02132
William P. Milberg
Affiliation:
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Brockton/West Roxbury Division, West Roxbury, MA 02132 Department of Psychiatry, Harvard University Medical School, Boston, MA 02115 Memory Disorders Research Center, Boston University School of Medicine, Boston, MA 02115
Mieke Verfaellie
Affiliation:
Memory Disorders Research Center, Boston University School of Medicine, Boston, MA 02115
Michael Alexander
Affiliation:
Memory Disorders Research Center, Boston University School of Medicine, Boston, MA 02115 Neurology Department, Boston University School of Medicine, Braintree Hospital, Braintree, MA 02185
Mark D'Esposito
Affiliation:
Neurology Department, University of Pennsylvania Medical Center, Philadelphia, PA 19104
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Abstract

In the current study, we investigated whether standard assessment techniques of visuospatial neglect are sensitive to detecting dissociable subtypes. We administered a battery of tasks commonly used to detect the presence of visuospatial neglect to 120 patients with unilateral right hemisphere infarcts and, in most cases, performed a systematic analysis of their lesions to quantify and localize brain damage. Using a factor analysis, we discovered seven relatively independent constructs, three of which were specifically related to the presence of left hemispatial neglect: Left Attentional Processing, Line Bisection. and Word Reading. Impairments in two of these factors. Left Attentional Processing and Line Bisection, occurred together in most cases but also occurred independently in 38 cases. There were no cases in whom Word Reading was present without concomitant deficits in one or the other two factors. These three factors could not be distinguished neuroanatomically; that is, lesions were equally likely in the temporal/parietal cortex, dorsolateral frontal cortex, or in deep frontal structures. These data confirm the notion that hemispatial neglect is a complex and multifaceted disorder composed of cognitively independent processes. These processes, however, cannot be dissociated neuroanatomically based on currently available assessment techniques. (JINS, 1996, 2, 441–451.)

Keywords

Hemispatial NeglectVisual searchLine bisectionNeglect dyslexiaBehavioral dissociation
Type
Thematic Articles
Information
Journal of the International Neuropsychological Society , Volume 2 , Issue 5 , September 1996 , pp. 441 - 451
Copyright
Copyright © The International Neuropsychological Society 1996

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