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The role of radiotherapy for large and locally advanced non-melanoma skin carcinoma

Published online by Cambridge University Press:  13 February 2012

Chance Matthiesen ,
Christina Forest ,
J. Spencer Thompson ,
Salahuddin Ahmad ,
Terence Herman  and
Carl Bogardus
Chance Matthiesen*
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Christina Forest
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
J. Spencer Thompson
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Salahuddin Ahmad
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Terence Herman
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Carl Bogardus
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
*
Correspondence to: Chance Matthiesen, MD, Stephenson Oklahoma Cancer Center, 800 N.E. 10th Street, OKCC L100, Oklahoma City, OK 73104, USA. Tel: 405-271-3016; Fax: 405-271-9240. E-mail: chance-matthiesen@ouhsc.edu
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Abstract

Background: The role of radiotherapy for large and locally advanced non-melanoma skin cancer is unclear. In this report, we aimed to review our institutional experience with patients treated with radiation therapy for T2–T4 NMSC and analyze outcomes.

Methods: Seventy patients and 85 lesions were reviewed who received radiotherapy. Fifty-six lesions (65.9%) were untreated, 17 (20.0%) recurrent, and 12 (14.1%) post-operative. Forty-three (50.6%) were staged T2, 20 (23.5%) T3, and 22 (25.9%) T4. Median follow-up was 20 months.

Results: Thirty-nine living patients (59.0%) had no evidence of disease, of which 35 (89.7%) required no therapy following radiotherapy. Twenty-seven patients (41.0%) died, of which 10 deaths were attributed to disease progression. Achievement of complete response (CR) to all therapy and radiotherapy alone was, respectively, 95.3% and 86% for T2, 70% and 65% for T3, and 68.2% and 59.1% for T4. Statistically significant factors for CR included basal cell histology (p = 0.005) and tumour stage T2 (0.01).

Conclusions: Radiotherapy for T2–T4 NMSC is effective. Basal cell histology and T2 are statistically favoured to achieve CR to radiotherapy alone.

Keywords

Non-melanoma skin cancerradiotherapyIMRT
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 12 , Issue 1 , March 2013 , pp. 56 - 65
Copyright
Copyright © Cambridge University Press 2013

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