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Radiotherapy in desmoid fibromatosis: a 10-year experience from a tertiary care centre

  • Sunitha S. Varghese (a1), Sharief Sidhique (a1), Anne J. Prabhu (a2), Simon P. Pavamani (a1), B. Antonysamy (a3), Vijay T. K. Titus (a4), Sukriya Nayak (a5) and Selvamani Backianathan (a1)...

Abstract

Aim of the study:

To assess the relapse-free survival (RFS) and the factors influencing local recurrence in patients with desmoid fibromatosis (DF) treated at our centre and to determine the role of post-operative radiotherapy (RT) in improving local control.

Methods:

A retrospective analysis of 51 patients treated for DF from January 2004 to December 2013 was undertaken. The RFS was calculated using the Kaplan–Meier curve. Univariate analysis was done to assess correlation with tumour size, site, the extent of surgery, margin status and adjuvant RT with RFS.

Results:

The median age was 28 years with a male:female ratio of 1:3. The most common location of the tumour was anterior abdominal wall (47%). The median tumour size was 10 cm. Wide local excision was done in most patients. Complete resection with negative margin was achieved in eight patients. Post-operative RT was indicated for 43 patients of whom 19 received RT. At a median follow-up of 37 months, RFS in the complete resection with margin negative group was 100%. RFS for the patients with positive or close margins who received RT was 79% and for those who did not receive RT, it was 87%.

Conclusions:

Complete excision with negative margins gives the best local control in DF. The benefit of post-operative RT could not be ascertained.

Copyright

Corresponding author

Author for correspondence: Sunitha Susan Varghese, Christian Medical College and Hospital Vellore, Vellore 632004, India. E-mail: sunithasusanvarghese@gmail.com

References

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Keywords

Radiotherapy in desmoid fibromatosis: a 10-year experience from a tertiary care centre

  • Sunitha S. Varghese (a1), Sharief Sidhique (a1), Anne J. Prabhu (a2), Simon P. Pavamani (a1), B. Antonysamy (a3), Vijay T. K. Titus (a4), Sukriya Nayak (a5) and Selvamani Backianathan (a1)...

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