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Radiotherapy in desmoid fibromatosis: a 10-year experience from a tertiary care centre

Published online by Cambridge University Press:  13 November 2019

Sunitha S. Varghese Open the ORCID record for Sunitha S. Varghese [Opens in a new window] ,
Sharief Sidhique ,
Anne J. Prabhu ,
Simon P. Pavamani ,
B. Antonysamy ,
Vijay T. K. Titus ,
Sukriya Nayak  and
Selvamani Backianathan
Sunitha S. Varghese*
Affiliation:
Department of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India
Sharief Sidhique
Affiliation:
Department of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India
Anne J. Prabhu
Affiliation:
Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India
Simon P. Pavamani
Affiliation:
Department of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India
B. Antonysamy
Affiliation:
Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India
Vijay T. K. Titus
Affiliation:
Department of Orthopedics, Christian Medical College, Vellore, Tamil Nadu, India
Sukriya Nayak
Affiliation:
Department of General Surgery, Christian Medical College, Vellore, Tamil Nadu, India
Selvamani Backianathan
Affiliation:
Department of Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu, India
*
Author for correspondence: Sunitha Susan Varghese, Christian Medical College and Hospital Vellore, Vellore 632004, India. E-mail: sunithasusanvarghese@gmail.com
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Abstract

Aim of the study:

To assess the relapse-free survival (RFS) and the factors influencing local recurrence in patients with desmoid fibromatosis (DF) treated at our centre and to determine the role of post-operative radiotherapy (RT) in improving local control.

Methods:

A retrospective analysis of 51 patients treated for DF from January 2004 to December 2013 was undertaken. The RFS was calculated using the Kaplan–Meier curve. Univariate analysis was done to assess correlation with tumour size, site, the extent of surgery, margin status and adjuvant RT with RFS.

Results:

The median age was 28 years with a male:female ratio of 1:3. The most common location of the tumour was anterior abdominal wall (47%). The median tumour size was 10 cm. Wide local excision was done in most patients. Complete resection with negative margin was achieved in eight patients. Post-operative RT was indicated for 43 patients of whom 19 received RT. At a median follow-up of 37 months, RFS in the complete resection with margin negative group was 100%. RFS for the patients with positive or close margins who received RT was 79% and for those who did not receive RT, it was 87%.

Conclusions:

Complete excision with negative margins gives the best local control in DF. The benefit of post-operative RT could not be ascertained.

Keywords

Desmoid fibromatosismargin statusradiotherapyrelapse-free survival
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 19 , Issue 3 , September 2020 , pp. 259 - 264
Copyright
© Cambridge University Press 2019

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