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Is wheat germ grass detrimental during radiotherapy?: a hypothesis

  • Tejinder Kataria (a1), Deepak Gupta (a1), Sasikumar Sambasivam (a1), Nisha T. Vishnu (a1), Shikha Goyal (a1), Shyam Singh Bisht (a1), Trinanjan Basu (a1), Ashu Abhishek (a1), Kushal Narang (a1) and Susovan Banerjee (a1)...



Antioxidant therapies to control oxidative damage have already attracted worldwide attention in recent years. Extensive studies on phytochemicals in cell culture system and animal models have provided a wealth of information on the mechanism by which such nutraceuticals show their beneficial effect. Nutraceuticals include plant-derived factors (phytochemicals) and factors derived from animal sources as well as from microbial sources. The activities of nutraceuticals are broad and include antioxidation, modulation of enzyme activity and modification of natural hormonal activity (agonist or antagonist) to act as a precursor for one or more beneficial molecules. Antioxidants scavenge free radicals that cause cell damage. Antioxidant consumption during radiotherapy and its effects are still controversial. Some studies suggest that antioxidant supplementation during chemotherapy or radiotherapy may be beneficial and some, harmful. Wheat grass is rich in superoxide dismutase, an antioxidant enzyme. Radiotherapy causes tumour cell kill via activation of reactive oxygen species, specifically by the hydroxyl radical and needs the reactive species for effective tumour control. Wheat grass which is rich in free radical scavengers can interfere with reactive oxygen species generated by radiation for tumour cell kill and can be detrimental to the therapy per se.


To hypothesise if the antioxidant properties of wheat grass could influence tumour activity, the effects of radiation therapy on tumour cells can be nullified when wheat grass is taken during radiotherapy.


Corresponding author

Correspondence to: Deepak Gupta, Radiation Oncology, Medanta – The Medicity, Gurgaon, Haryana, India. Tel: 918860261459. E-mail:


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1. Das, L, Bhaumik, E, Raychaudhuri, U, Chakraborty, R. Role of nutraceuticals in human health. J Food Sci Technol 2012; 49: 173183.
2. Lampe, J W. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 1999; 70: 475S490SS.
3. Marx, J L. Oxygen free radicals linked to many diseases. Science 1985; 235: 529531.
4. Godsey, J, Grundmann, O. Review of various herbal supplements as complementary treatments for oral cancer. J Diet Suppl 2016; 13 (5): 538550.
5. Norman, H, Butrum, R, Feldman, E et al. The role of dietary supplements during cancer therapy. J Nutr 2003; 133: 3794S3799S.
6. Bairati, I, Meyer, F, Jobin, E et al. Antioxidant vitamins supplementation and mortality: a randomized trial in headand neck cancer patients. Int J Cancer 2006; 119: 22212224.
7. Greenlee, H, Hershman, D, Jacobson, J. Use of antioxidant supplements during breast cancer treatment: a comprehensive review. Breast Cancer Res Treat 2009; 115: 437452.
8. Doughari, J H, Human, I S, Bennade, S, Ndakidemi, P A. Phytochemicals as chemotherapeutic agents and antioxidants: possible solution to the control of antibiotic resistant verocytotoxin producing bacteria. J Med Plants Res 2009; 3 (11): 839848.
9. Milner, J A. Functional foods: the US perspective. Am J Clin Nutr 2000; 71 (suppl): 1654 S1659 S.
10. Eisenberg, D M, Davis, R B, Ettner, S L et al. Trends in alternative medicine use in United States, 1990–1997: results of a followup national survey. J Am Med Assoc 1998; 280: 15691575.
11. Marcus, D M, Grollman, A P. Botanical medicine-the need for new regulations. New Eng J Med 2002; 347: 20732076.
12. Tindle, H A, Davis, R B, Phillip, R S, Eisenberg, D M. Trends in use of complementary and alternative medicine by US adults:1997–2002. Altern Ther Health Med 2005; 11: 4249.
13. Wigmore, A. Be your own doctor: a positive guide to natural living. Avery 1982.
14. Cassileth, B. Contemporary unorthodox treatments in cancer medicine: a study of patients, treatments, and practitioners. Ann Intern Med 1984; 101: 105112.
15. Bidlack, W R, Meskin, M S. Nutritional quackery: selling health misinformation,. Calif Pharmacist 1989; 36 (8): 34.
16. Jirathitikal, V. Inventor; Immunitor USA Inc., assignee. Drug for AIDS treatment. United States patent US 7384,637. 10 June 2008.
17. Mujoriya, R, Bodla, R B. A study on wheat grass and its nutritional value. Food Sci Qual Manag 2011; 2: 19.
18. Cassileth, B R, Brown, H. Unorthodox cancer medicine. CA Cancer J Clin 1988; 38 (3): 176186.
19. Fang, Y Z, Yang, S, Wu, G. Free radicals, antioxidants, and nutrition. Nutrition 2002; 18 (10): 872879.
20. Block, K, Koch, M, Mead, M, Tothy, P, Newman, R, Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trails. Int J Cancer 2008; 123: 12271239.
21. Block, K, Koch, A, Mead, M, Tothy, P, Newman, R, Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of theevidence from randomized controlled trials. Cancer Treat Rev 2007; 33: 407418.
22. Conklin, K. Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer 2000; 37: 118.
23. Mates, M J, Jimenez, S, Fransisca, M. Role of reactive oxygen species in apoptosis: implication for cancer therapy. Int J Biochem Cell Biol 2000; 32 (2): 157170.
24. Hall, E, Giaccia, A. Radiobiology for the Radiologist. Philadelphia: Lippincott Williams & Wilkins, 2006.
25. Kothari, S, Jain, A K, Mehta, S C et al. Hypolipidemic effect of fresh Triticum aestivum (wheat) grass juice in hypercholesterolemic rats. Acta Pol Pharm 2011; 68 (2): 291294.
26. Sethi, J, Yadav, M, Dahiya, K et al. Antioxidant effect of Triticum aestivium (wheat grass) in high-fat diet-induced oxidative stress in rabbits. Methods Find Exp Clin Pharmacol 2010; 32 (4): 233235.
27. Shyam, R, Singh, S N, Vats, P et al. Wheat grass supplementation decreases oxidative stress in healthy subjects: a comparative study with spirulina. J Altern Complement Med. 2007; 13 (8): 789791.
28. Ben-Arye, E, Goldin, E, Wengrower, D et al. Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002; 37 (4): 444449.
29. Ng, S C, Lam, Y T, Tsoi, K K et al. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Aliment Pharmacol Ther 2013; 38 (8): 854863.
30. Marawaha, R K, Bansal, D, Kaur, S et al. Wheat grass juice reduces transfusion requirement in patients with Thalassemia major: a pilot study. Indian Pediatr 2004; 41 (7): 716720.
31. Choudhary, D R, Naithani, R, Panigrahi, I et al. Effect of wheat grass therapy on transfusion requirement in beta-Thalassemia major. Indian J Pediatr 2009; 76 (4): 375376.
32. Singh, K, Pannu, M S, Singh, P et al. Effect of wheat grass tablets on the frequency of blood transfusions in Thalassemia major. Indian J Pediatr 2010; 77 (1): 9091.
33. Bar-Sela, G, Tsalic, M, Fried, G et al. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. Nutr Cancer 2007; 58 (1): 4348.
34. Mukhopadhyay, S et al. The role of iron chelation activity of wheat grass juice in patients with myelodysplastic syndrome. J Clin Oncol 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 27 (15S): 7012.
35. Dey, S, Sarkar, R, Ghosh, P et al. Effect of wheat grass juice in supportive care of terminally ill cancer patients – a tertiary cancer centre experience from India. J Clin Oncol 2006 ASCO Meeting Proceedings Part I; 18 (1): 8634.
36. Lai, C N, Dabney, B, Shaw, C. Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts. Nutr Cancer 1978; 1 (1): 2730.
37. Lai, C N. Chlorophyll: the active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro. Nutr Cancer 1979; 1 (3): 1921.
38. Chiu, L C, Kong, C K, Ooi, V E. The chlorophyllin induced cell cycle arrest and apoptosis in human breast cancer MCF 7 cells isassociated with ERK deactivation and Cyclin D1 depletion. Int J Mol Med 2005; 16 (4): 735740.
39. Egner, P A, Wang, J B, Zhu, Y R et al. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci USA 2001; 98 (25): 1460114606.
40. Guo, D, Schut, H A, Davis, C D, Snyderwine, E G, Bailey, G S, Dashwood, R H. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo 4,5-b, pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 1995; 16 (12): 29312937.
41. Pratt, M M, Reddy, A P, Hendricks, J D, Pereira, C, Kensler, T W, Bailey, G S. The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. Carcinogenesis 2007; 28 (3): 611624.
42. Sarkar, D, Sharma, A, Talukder, G. Chlorophyll and chlorophyllin as modifiers of genotoxic effects. Mutat Res 1994; 318 (3): 239247.
43. Tachino, N, Guo, D, Dashwood, W M, Yamane, S, Larsen, R, Dashwood, R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res 1994; 308 (2): 191203.
44. Guengerich, F P, Kim, D H, Iwasaki, M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 1991; 4: 168207.
45. Finch, C E, Tanzi, R E. Genetics of aging. Science 1997; 278 (5337): 407411.
46. Wheat, J, Currie, G. Herbal medicine for cancer patients: an evidence based review. Internet J Altern Med 2008; 5 (2): 23.
47. Mates, M J, Jimenez, S, Fransisca, M. Role of reactive oxygen species in apoptosis: implication for cancer therapy. Int J Biochem Cell Biol 2000; 32 (2): 157170.
48. Peryty, B, Szmczyk, T, Lesca, P. Mechanism of antimutagenicity of wheat sprout extract. Mut Res 1992; 269: 201215.
49. Zirkle, R E. The radiobiological importance of linear energy transfer. Radiat Biol 1954; 1 (Pt 1): 315350.
50. Hunter, N, Muirhead, C R. Review of relative biological effectiveness dependence on linear energy transfer for low-LET radiations. J Radiol Prot 2009; 29 (1): 5.
51. Fridovich, I. The biology of oxygen radicals. Science 1978; 201 (4359): 875880.
52. Brooker, R. Genetics. New York, NY: McGraw-Hill; 2009.
53. Lawenda, B, Kelly, K, Ladas, E, Sagar, S, Vickers, A, Blumberg, J. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J NCI Journal of the National Cancer Institute 2008; 100: 773783.
54. Ladas, E, Kelly, K M. The antioxidant debate. Explore (NY) 2010; 6: 7585.
55. Greenlee, H, Kwan, M, Kushi, L et al. Antioxidant supplement use after breast cancer diagnosis and mortality in the Life After Cancer Epidemiology (LACE) cohort. Cancer 2012; 118: 20482058.


Is wheat germ grass detrimental during radiotherapy?: a hypothesis

  • Tejinder Kataria (a1), Deepak Gupta (a1), Sasikumar Sambasivam (a1), Nisha T. Vishnu (a1), Shikha Goyal (a1), Shyam Singh Bisht (a1), Trinanjan Basu (a1), Ashu Abhishek (a1), Kushal Narang (a1) and Susovan Banerjee (a1)...


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