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Quality of life in a sample of schizophrenic patients with and without metabolic syndrome

Published online by Cambridge University Press:  13 July 2010

Tomás Sánchez-Araña Moreno ,
Sergio Ruiz-Doblado ,
José Luis Hernández-Fleta ,
Ramon Touriño-Gonzalez  and
Petra León-Pérez
Tomás Sánchez-Araña Moreno
Affiliation:
Psychiatric Services, Puerto Real University Hospital, Cadiz, Spain
Sergio Ruiz-Doblado*
Affiliation:
Chairman, Psychiatric and Mental Health Services, Osuna Hospital, Seville, Spain
José Luis Hernández-Fleta
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
Ramon Touriño-Gonzalez
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
Petra León-Pérez
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
*
Correspondence to: Sergio Ruiz-Doblado, Servicio de Psiquiatra, Hospital de Osuna, Avda. Constitución, 2, Osuna, Sevilla 41640, Spain. Tel: +34 955077257; Fax: +34 955077257; E-mail: sergioruiz@ozu.es
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Abstract

Introduction: Quality of life is an important measure of results in psychiatry in general, and in the treatment of schizophrenia in particular. The metabolic syndrome has a strong prevalence in schizophrenia, and can have an impact on quality of life.

Objective: To compare the perceived quality of life of a sample of schizophrenic patients with and without metabolic syndrome.

Methods: Cross-sectional observational study, including 136 patients (49 with metabolic syndrome) admitted in 2004 to a short-term hospitalization psychiatric unit with a diagnosis of schizophrenia or schizoaffective disorder validated using the SCID-I. Metabolic syndrome defined according to NCEP-ATP III criteria. Quality of life assessed using the EuroQol 5D. Simple associative, and multivariate analysis (logistic regression) were performed.

Results: In the schizophrenic patients studied, metabolic syndrome is associated with age (p = 0.035), pension beneficiary (p = 0.005), antipsychotics treatment (p = 0.017), years of evolution (p = 0.008), and also with a lower score on the EuroQol 5D ‘health state today’ (p = 0.035) and ‘mobility’ (p = 0.011) dimensions. Multivariate analysis (logistic regression) shows that quality of life is mainly associated with age (OR = 3.2), metabolic syndrome (OR = 2.6) and mobility problems (OR = 2).

Conclusion: When treating schizophrenic patients, we should take into account comorbidity with metabolic syndrome, since the latter, in addition to representing a significant cardiovascular risk factor, can also affect, added to treatment issues, illness factors and other social and environmental variables, the patient’s quality of life.

Keywords

Schizophreniametabolic syndromequality of life
Type
Original Article
Information
Journal of Psychiatric Intensive Care , Volume 6 , Issue 2 , December 2010 , pp. 101 - 108
Copyright
Copyright © NAPICU 2010

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