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Quality of life in a sample of schizophrenic patients with and without metabolic syndrome

Published online by Cambridge University Press:  13 July 2010

Tomás Sánchez-Araña Moreno
Affiliation:
Psychiatric Services, Puerto Real University Hospital, Cadiz, Spain
Sergio Ruiz-Doblado*
Affiliation:
Chairman, Psychiatric and Mental Health Services, Osuna Hospital, Seville, Spain
José Luis Hernández-Fleta
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
Ramon Touriño-Gonzalez
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
Petra León-Pérez
Affiliation:
Psychiatric Department, Grand Canary Dr Negrin University Hospital & School of Medicine, Canary Islands, Spain
*
Correspondence to: Sergio Ruiz-Doblado, Servicio de Psiquiatra, Hospital de Osuna, Avda. Constitución, 2, Osuna, Sevilla 41640, Spain. Tel: +34 955077257; Fax: +34 955077257; E-mail: sergioruiz@ozu.es
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Abstract

Introduction: Quality of life is an important measure of results in psychiatry in general, and in the treatment of schizophrenia in particular. The metabolic syndrome has a strong prevalence in schizophrenia, and can have an impact on quality of life.

Objective: To compare the perceived quality of life of a sample of schizophrenic patients with and without metabolic syndrome.

Methods: Cross-sectional observational study, including 136 patients (49 with metabolic syndrome) admitted in 2004 to a short-term hospitalization psychiatric unit with a diagnosis of schizophrenia or schizoaffective disorder validated using the SCID-I. Metabolic syndrome defined according to NCEP-ATP III criteria. Quality of life assessed using the EuroQol 5D. Simple associative, and multivariate analysis (logistic regression) were performed.

Results: In the schizophrenic patients studied, metabolic syndrome is associated with age (p = 0.035), pension beneficiary (p = 0.005), antipsychotics treatment (p = 0.017), years of evolution (p = 0.008), and also with a lower score on the EuroQol 5D ‘health state today’ (p = 0.035) and ‘mobility’ (p = 0.011) dimensions. Multivariate analysis (logistic regression) shows that quality of life is mainly associated with age (OR = 3.2), metabolic syndrome (OR = 2.6) and mobility problems (OR = 2).

Conclusion: When treating schizophrenic patients, we should take into account comorbidity with metabolic syndrome, since the latter, in addition to representing a significant cardiovascular risk factor, can also affect, added to treatment issues, illness factors and other social and environmental variables, the patient’s quality of life.

Type
Original Article
Copyright
Copyright © NAPICU 2010

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References

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