The authors thank the subjects enrolled in the study for their contribution to our research. Additionally, we would like to thank the Herta Messerli Stiftung for financial support and positive feedback. Furthermore, we thank the technical staff at Rigshopitalet (Dorte Christensen, Birgitte Schou and Jette Christiansen) and at NEXS (Department of Nutrition, Exercise and Sports, University of Copenhagen; Pia Madsen and Cecilie Appeldorff) for technical support conducting the study and ultra-HPLC analyses. Lastly, we would like to thank optometrist Hajer Ahmad for valuable contributions to the clinical eye examinations, and Dr Elizabeth Johnson who so generously let us use the lutein/zeaxanthin screener.
The study was initiated by J. N. E., L. O. D., M. L., P. B. J. and E. A. The research question was formulated and the study designed by the initiating group. The study was carried out by J. N. E., M. L., P. B. J., A. P. P. and M. K. F. Data were analysed and the paper drafted by J. N. E. Each of the listed authors reviewed and commented on the paper draft before submission.
There were no conflicts of interest.
Ma, L, Dou, HL, Wu, YQ, et al. (2012) Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr
Schmidl, D, Garhofer, G & Schmetterer, L (2015) Nutritional supplements in age-related macular degeneration. Acta Ophthalmol
del Rocío Gómez-García, M & Ochoa-Alejo, N (2013) Biochemistry and molecular biology of carotenoid biosynthesis in chili peppers (Capsicum spp.). Int J Molec Sci
Bohn, T, Desmarchelier, C, Dragsted, LO, et al. (2017) Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Mol Nutr Food Res
Matarese, LE (2012) Nutrition and fluid optimization for patients with short bowel syndrome. J Parenter Enteral Nutr
Moran, R, Johnson, EJ, Stack, E, et al. (2014) The relationship between dietary intake of lutein and zeaxanthin and their concentration in serum: introduction of a novel carotenoid dietary screener. International Carotenoid Symposium 2014, Park City, UT, USA.
Eriksen, JN, Madsen, PL, Dragsted, LO, et al. (2017) Optimized, fast-throughput UHPLC-DAD based method for carotenoid quantification in spinach, serum, chylomicrons, and feces. J Agric Food Chem
Geerling, BJ, Badart-Smook, A, Stockbrugger, RW, et al. (2000) Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr
Drai, J, Borel, P, Faure, H, et al. (2009) Fasting plasma carotenoids concentrations in Crohn's and pancreatic cancer patients compared to control subjects. Int J Vitam Nutr Res
Renner, AB, Dietrich-Ntoukas, T & Jagle, H (2015) Recurrent episodes of night blindness in a patient with short bowel syndrome. Doc Ophthalmol
da Rocha Lima, B, Pichi, F & Lowder, CY (2014) Night blindness and Crohn's disease. Int Ophthalmol
Schupp, C, Olano-Martin, E, Gerth, C, et al. (2004) Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Am J Clin Nutr
Shi, AJ, Morrissey, BM, Durbin-Johnson, B, et al. (2014) Macular pigment and macular volume in eyes of patients with cystic fibrosis. Free Radic Res