1.Bouillon, R & Suda, T (2014) Vitamin D: calcium and bone homeostasis during evolution. Bonekey Rep 3, 480.
2.Bendik, I, Friedel, A, Roos, FF, et al. (2014) Vitamin D: a critical and essential micronutrient for human health. Front Physiol 5, 248.
3.Rosen, CJ (2011) Vitamin D insufficiency. N Engl J Med 364, 248–254.
4.Bouillon, R (2017) Comparative analysis of nutritional guidelines for vitamin D. Nat Rev Endocrinol 13, 466–479.
5.Rosen, CJ, Adams, JS, Bikle, DD, et al. (2012) The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 33, 456–492.
6.Zittermann, A, Pilz, S, Hoffmann, H, et al. (2016) Vitamin D and airway infections: a European perspective. Eur J Med Res 21, 14.
7.Dror, DK & Allen, LH (2010) Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev 68, 465–477.
9.Göring, H (2018) Vitamin D in nature: a product of synthesis and/or degradation of cell membrane components. Biochemistry (Mosc) 83, 1350–1357.
10.Liu, X, Baylin, A & Levy, PD (2018) Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications. Br J Nutr 119, 928–936.
11.Brouwer-Brolsma, EM, Vaes, AMM, van der Zwaluw, NL, et al. (2016) Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: the B-PROOF study. J Steroid Biochem Mol Biol 164, 168–176.
12.Jolliffe, DA, Walton, RT, Griffiths, CJ, et al. (2016) Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: review of genetic association studies. J Steroid Biochem Mol Biol 164, 18–29.
13.Touvier, M, Deschasaux, M, Montourcy, M, et al. (2015) Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors. J Invest Dermatol 135, 378–388.
14.Davey Smith, G & Hemani, G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23, R89–R98.
15.Gupta, V, Walia, GK & Sachdeva, MP (2017) ‘Mendelian randomization’: an approach for exploring causal relations in epidemiology. Public Health 145, 113–119.
16.Alharbi, O & El-Sohemy, A (2017) Lactose intolerance (LCT-13910C>T) genotype is associated with plasma 25-hydroxyvitamin D concentrations in Caucasians: a Mendelian randomization study. J Nutr 147, 1063–1069.
18.Itan, Y, Powell, A, Beaumont, MA, et al. (2009) The origins of lactase persistence in Europe. PLoS Comput Biol 5, e1000491.
19.Schmid, A & Walther, B (2013) Natural vitamin D content in animal products. Adv Nutr 4, 453–462.
20.Sorthe, J & Moghaddam, A (2019) Lactase persistence may explain the paradoxical findings of high vitamin D concentrations in Europeans living in areas of low UV-B irradiation. Eur J Clin Nutr 73, 585–593.
21.REK (2018) Regionale komiteer for medisinsk og helsefaglig forskningsetikk (Regional committees for medical and health research ethics). https://helseforskning.etikkom.no (accessed April 2018).
22.Bergholdt, HK, Nordestgaard, BG & Ellervik, C (2015) Milk intake is not associated with low risk of diabetes or overweight-obesity: a Mendelian randomization study in 97,811 Danish individuals. Am J Clin Nutr 102, 487–496.
23.Bergholdt, HKM, Nordestgaard, BG, Varbo, A, et al. (2018) Lactase persistence, milk intake, and mortality in the Danish general population: a Mendelian randomization study. Eur J Epidemiol 33, 171–181.
24.Lehtimäki, T, Hutri-Kähönen, N, Kähönen, M, et al. (2008) Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: The Cardiovascular Risk in Young Finns Study. Clin Sci 115, 265–271.
25.Obermayer-Pietsch, BM, Bonelli, CM, Walter, DE, et al. (2004) Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 19, 42–47.
27.Ségurel, L & Bon, C (2017) On the evolution of lactase persistence in humans. Annu Rev Genomics Hum Genet 18, 297–319.
28.Shaukat, A, Levitt, MD, Taylor, BC, et al. (2010) Systematic review: effective management strategies for lactose intolerance. Ann Intern Med 152, 797.
29.Sibley, E (2004) Genetic variation and lactose intolerance: detection methods and clinical implications. Am J Pharmacogenomics 4, 239–245.
30.Ding, M, Huang, T, Bergholdt, HK, et al. (2017) Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. Br Med J 356, j1000.
31.Enko, D, Kriegshäuser, G, Stolba, R, et al. (2016) Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption. Eur J Clin Nutr 70, 1000–1003.
32.Opplysningskontoret for Meieriprodukter (Dairy Information Office) (2019) Statistikk for meieriprodukter fra 2007 (Statistics for dairy products from 2007). https://www.melk.no/Statistikk (accessed February 2019).
33.Gilchrest, BA (2008) Sun exposure and vitamin D sufficiency. Am J Clin Nutr 88, 570S–577S.
34.Rockell, JEP, Skeaff, CM, Williams, SM, et al. (2008) Association between quantitative measures of skin color and plasma 25-hydroxyvitamin D. Osteoporos Int 19, 1639.
35.Yang, Q, Lin, SL, Au Yeung, SL, et al. (2017) Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study. Eur J Clin Nutr 71, 1008–1012.
36.Lember, M, Torniainen, S, Kull, M, et al. (2006) Lactase non-persistence and milk consumption in Estonia. World J Gastroenterol 12, 7329–7331.
37.Manios, Y, Moschonis, G, Grammatikaki, E, et al. (2015) Food group and micronutrient intake adequacy among children, adults and elderly women in Greece. Nutrients 7, 1841–1858.
38.Smith, CE, Coltell, O, Sorlí, JV, et al. (2016) Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep 6, 33188.
39.Lapides, RA & Savaiano, DA (2018) Gender, age, race and lactose intolerance: is there evidence to support a differential symptom response? A scoping review. Nutrients 10, E1956.
40.Afify, SM & Pali-Schöll, I (2017) Adverse reactions to food: the female dominance – a secondary publication and update. World Allergy Organ J 10, 43.
41.Nair, S (2010) Vitamin D deficiency and liver disease. Gastroenterol Hepatol (N Y) 6, 491–493.
42.Allen, KJ, Gurrin, LC, Constantine, CC, et al. (2008) Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 358, 221–230.
43.Piyathilake, CJ, Macaluso, M, Hine, RJ, et al. (1994) Local and systemic effects of cigarette smoking on folate and vitamin B-12. Am J Clin Nutr 60, 559–566.
45.Liebert, A, López, S, Jones, BL, et al. (2017) World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection. Hum Genet 136, 1445–1453.
46.Clemens, TL, Adams, JS, Henderson, SL, et al. (1982) Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet i, 74–76.
47.Holvik, K, Meyer, HE, Søgaard, AJ, et al. (2007) Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnic Norwegians. The Oslo Health Study. BMC Endocr Disord 7, 9.
48.Juzeniene, A, Baturaite, Z, Lagunova, Z, et al. (2015) Influence of multiple UV exposures on serum cobalamin and vitamin D levels in healthy females. Scand J Public Health 43, 324–330.
49.Juzeniene, A & Nizauskaite, Z (2013) Photodegradation of cobalamins in aqueous solutions and in human blood. J Photochem Photobiol B Biol 122, 7–14.
50.Machiela, MJ & Chanock, SJ (2015) LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics 31, 3555–3557.
51.Hart, KL, Kimura, SL, Mushailov, V, et al. (2013) Improved eye- and skin-color prediction based on 8 SNPs. Croat Med J 54, 248–256.
52.Li, S-S, Gao, L-H, Zhang, X-Y, et al. (2016) Genetically low vitamin D levels, bone mineral density, and bone metabolism markers: a Mendelian randomisation study. Sci Rep 6, 33202.
53.Jacobs, ET, Van Pelt, C, Forster, RE, et al. (2013) CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells. Cancer Res 73, 2563–2573.
54.Jiang, X, Kiel, DP & Kraft, P (2019) The genetics of vitamin D. Bone 126, 59–77.
55.Flatz, G & Rotthauwe, HW (1973) Lactose nutrition and natural selection. Lancet ii, 76–77.
56.Andersen, LB, Jørgensen, JS, Jensen, TK, et al. (2015) Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. Am J Clin Nutr 102, 633–638.
57.Conway, KS & Trudeau, J (2019) Sunshine, fertility and racial disparities. Econ Hum Biol 32, 18–39.
58.Sheikh, A, Saeed, Z, Jafri, SAD, et al. (2012) Vitamin D levels in asymptomatic adults – a population survey in Karachi, Pakistan. PLOS ONE 7, e33452.