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Ascorbic Acid Levels in Patients Suffering from Psychoses of the Senium

  • Donald G. Remp (a1), S. R. Rosen (a1), John B. Ziegler (a1) and D. Ewen Cameron (a1)


Numerous workers (Plaut, 1935; Altaman, 1937; Monouni, 1937) have reported that the blood and spinal fluid ascorbic acid levels are low in the aged. No adequate explanation of this fact has been given. Wortis (1938) has suggested that, since oral administration increases the ascorbic acid level of the spinal fluid in the aged as in the young, defective absorption probably does not play a significant part. He believes that the lower values in older persons may be due to increased intensity of metabolic processes concerned with the elaboration of ascorbic acid. Friedman, in discussing this contribution, advanced the suggestion that in older persons there may be less need for ascorbic acid because metabolism is slowed.



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Altaman, O., and Goldhammer, H. (1937), “Excretion of Cevitamic Acid in Urine and Content of Cerebro-spinal Fluid in Nervous Diseases,” Klin. Wochenschr., 16, 17931795.
Benedict, F. G. (1935), “Old Age and Basal Metabolism,” N.E.J. Med., 212, 11111122.
Lewis, W. H. (1938), “Changes with Age in Basal Metabolic Rate in Adult Men,” Amer. Journ. Physiol., 121, 501516.
Matson, J. R., and Hitchcock, F. A. (1934), “Basal Metabolism and Age,” ibid., 110, 329341.
Mindelin, R. L., and Butler, A. M. (1938), “Determination of Ascorbic Acid in Plasma, Macromethod and Micromethod,” Journ. Biol. Chem., 122, 673686.
Monouni, J. (1937), “Vitamin C Content of Cerebro-spinal Fluid in Mental Diseases,” Zeitschr. f. d. ges. Neur. u. Psychiat., 157, 636647.
Plaut, F., and Bülow, M. (1935), “Über den Einfluss der Nährung auf den C-Vitamingehalt des Liquor Cerebrospinalis,” ibid., 152, 324336.
Robinson, S. (1938), “Experimental Studies of Physical Fitness in Relation to Age,” Arbeitsphysiologie, 10, 251323.
Wortis, H., Wortis, S. B., and Marsh, F. I. (1938), “Role of Vitamin C in Metabolism of Nerve Tissue,” Arch. Neurol. and Psychiat., 39, 10551066.


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Ascorbic Acid Levels in Patients Suffering from Psychoses of the Senium

  • Donald G. Remp (a1), S. R. Rosen (a1), John B. Ziegler (a1) and D. Ewen Cameron (a1)
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