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Cysteine-functionalized zwitterionic ZnO quantum dots

Published online by Cambridge University Press:  19 July 2013

Osman Arslan ,
Aadesh P. Singh ,
Lhoussaine Belkoura  and
Sanjay Mathur
Osman Arslan
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, D-50939 Cologne, Germany
Aadesh P. Singh
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, D-50939 Cologne, Germany
Lhoussaine Belkoura
Affiliation:
Institute of Physical Chemistry, University of Cologne, D-50939 Cologne, Germany
Sanjay Mathur*
Affiliation:
Institute of Inorganic Chemistry, University of Cologne, D-50939 Cologne, Germany
*
a)Address all correspondence to this author. e-mail: sanjay.mathur@uni-koeln.de
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Abstract

Visible light emitting ZnO quantum dots (QDs) were synthesized by a modified sol–gel method and in situ coated with the amino acid cysteine to modify their surface chemistry and govern the crystal growth process. Surface chelation by a hydrophilic thiol such as cysteine offered a fine control over the particle size and modulated the optical emission and its stability by reducing the density of surfacial oxygen deficiencies and also induced the formation of hierarchical nanostructures in the solution. TEM and XRD results confirmed the formation of mono-dispersed and spherical ZnO QDs in the size range 2.5–3.8 nm. The modulation of band gap energies was manifested in the visible emission of cysteine modified QDs, which was found to be remarkably stable for cell labeling applications, when compared to the photoluminescence of conventional ZnO QDs.

Keywords

ZnOquantum dotscysteinesurface cappingvisible emission
Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 14 , 28 July 2013 , pp. 1947 - 1954
Copyright
Copyright © Materials Research Society 2013 

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Footnotes

b)

This author was an editor of this journal during the review and decision stage. For the JMR policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/jmr-editor-manuscripts/

References

REFERENCES

Huang, M.H., Mao, S., Feick, H., Yan, H., Wu, Y., Kind, H., Webber, E., Russo, R., and Yang, P.: Room-temperature ultraviolet nanowire nanolasers. Science 292, 1897 (2001).CrossRefGoogle ScholarPubMed
Baxter, J.B. and Aydil, E.S.: Nanowire based dye sensitized solar cells. Appl. Phys. Lett. 86, 53114, (2005).Google Scholar
Tang, X., Choo, E.S.G., Li, L., Ding, J., and Xue, J.: synthesis of ZnO nanoparticles with tunable emission colors and their cell labeling applications. Chem. Mater. 22, 3383 (2010).Google Scholar
Murray, C.B., Kagan, C.R., and Bawendi, M.G.: Synthesis and characterization of monodisperse nanocrystals and close-packed assemblies. Annu. Rev. Mater. Sci. 30, 545 (2000).Google Scholar
Murray, C.B., Norris, D.B., and Bawendi, M.G.: Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites. J. Am. Chem. Soc. 115, 8706 (1993).Google Scholar
Zeshan, H., Santos, J.F.H., Oskam, G., and Searson, P.C.: Influence of the reactant concentrations on the synthesis of ZnO nanoparticles. J. Coll. Int. Sci. 313, 288 (2005).Google Scholar
Mathur, S., Cavelius, C., and Shen, H.: CoGa2O4 nanoparticles and films using a single molecular source. Z. Anorg. Allg. Chem. 2106, 635 (2009).Google Scholar
El-Gamel, N.E.A., Wortmann, L., Arroub, K., and Mathur, S.: SiO2@Fe2O3 core-shell nanoparticles for covalent immobilization and release of sparfloxacin drug. Chem. Commun. 10076, 47 (2011).Google Scholar
Xiong, H.M., Wang, Z.D., Liu, D.P., Chen, J.S., Wang, Y.G., and Xia, Y.Y.: Bonding polyether onto ZnO nanoparticles: An effective method for preparing polymer nanocomposites with tunable luminescence and stable conductivity. Adv. Funct. Mater. 1751, 15 (2005).Google Scholar
Trindade, T., O'Brien, P., and Pickett, N.L.: Nanocrystalline semiconductors: Synthesis, properties and perspectives. Chem. Mater. 3843, 13 (2001).Google Scholar
Chang, C. and Fogler, H.S.: Controlled formation of silica particles from tetraethyl orthosilicate in nonionic water-in-oil microemulsions. Langmuir 3295, 13 (1997).Google Scholar
Noshir, S.P., Zeshan, H., Kathleen, J.S., and Searson, P.C.: Quenching of growth of ZnO nanoparticles by adsorption of octanethiol. J. Phys. Chem. B 6985, 106 (2002).Google Scholar
Hemmer, E., Kohl, Y., Colquhoun, V., Thielecke, H., Soga, K., and Mathur, S.: Probing cytotoxicity of gadolinium hydroxide nanostructures. J. Phys. Chem. B 4358, 114 (2010).Google Scholar
Willner, I. and Katz, E.: Integrated nanoparticle-biomolecule hybrid systems: Synthesis, properties and applications. Angew. Chem. Int. Ed. 6042, 43 (2004).Google Scholar
Wu, Q., Chen, X., Zhang, P., Han, Y., Chen, X., Yan, Y., and Li, S.: Amino acid-assisted synthesis of ZnO hierarchical architectures and their novel photocatalytic activities. Cryst. Growth Des. 3011, 8 (2008).Google Scholar
Dickerson, M.B., Sandhage, K.H., and Naik, R.R.: Protein- and peptide-directed syntheses of inorganic materials. Chem. Rev. 4935, 108 (2008).Google Scholar
Gerstel, P., Hoffmann, R.C., Lipowsky, P., Jeurgens, L.P.H., and Aldinger, J.B.F.: Mineralization from aqueous solutions of zinc salts directed by amino acids and peptides. Chem. Mater. 179, 18 (2006).Google Scholar
Rebilly, J.N., Gardner, P.W., Darling, G.R., Bacsa, J., and Rosseinsky, M.J.: Chiral II−VI semiconductor nanostructure superlattices based on an amino acid ligand. Inorg. Chem. 9390, 47 (2008).Google Scholar
Wong, E.M., Bonevich, J.E., and Searson, P.C.: Growth kinetics of nanocrystalline ZnO particles from colloidal suspensions. J. Phys. Chem. B 7770, 102 (1998).Google Scholar
Meulenkamp, E.A.: Synthesis and growth of ZnO nanoparticles. J. Phys. Chem. B 5566, 102 (1998).Google Scholar
Liu, L., Fu, L., Liu, Y., Liu, Y., Jiang, P., Liu, S., Gao, M., and Tang, Z.: Bioinspired synthesis of vertically aligned ZnO nanorod arrays: Toward greener chemistry. Cryst. Growth Des. 4793, 9 (2009).Google Scholar
Degen, A. and Kosec, M.: Effect of pH and impurities on the surface charge of zinc oxide in aqueous solution. J. Eur. Ceram. Soc. 667, 20 (2000).Google Scholar
Cockel, P., Vahrenkamp, H., and Zuberbühler, A.D.: Zinc complexes of cysteine, histidine, and derivatives thereof: Potentiometric determination of their compositions and stabilities. Helv. Chim. Acta 571, 76 (1993).Google Scholar
Arena, G., Musumeci, S., Rizzarelli, E., Sammartano, S., and Rigano, C.: Zinc(II)-cysteine and zinc(II) cystine systems: Selection of species from potentiometric data. Transition Met. Chem. 5(1), 297 (1980).CrossRefGoogle Scholar
Oskam, G., Hu, Z., Penn, R.L., Pesika, N., and Searson, P.C.: Coarsening of metal oxide nanoparticles. Phys. Rev. 11403, 66 (2002).Google Scholar
Jantz, D., Amann, B.T., Gatto, G.J., and Berg, J.M. Jr.: The design of functional DNA-binding proteins based on zinc finger domains. Chem. Rev. 789, 104 (2004).Google Scholar
Chang, H. and Matiyevic, E.: Interactions of metal hydrous oxides with chelating agents: IV. Dissolution of hematite. J. Colloid Interface Sci. 479, 92 (1983).Google Scholar
Meldrum, F.C. and Coelfen, H.: Controlling mineral morphologies and structures in biological and synthetic systems. Chem. Rev. 4332, 108 (2008).Google Scholar
Cha, J.N., Stucky, G.D., Morse, D.E., and Demin, T.J.: Biomimetic synthesis of ordered silica structures mediated by block copolypeptides. Nature 289, 403 (2000).Google Scholar
Tomczak, M.M., Gupta, M.K., Drummy, L.F., Rozenzhak, S.M., and Naik, R.R.: Morphological control and assembly of zinc oxide using a biotemplate. Acta Biomater. 876, 5 (2009).Google Scholar
Umetsu, M., Mizuta, M., Tsumoto, K., Ohara, S., Takami, S., Watanabe, H., Kumagai, I., and Adschiri, T.: Bioassisted room-temperature immobilization and mineralization of zinc oxide—the structural ordering of ZnO nanoparticles into a flower-type morphology Adv. Mater. 2571, 17 (2005).Google Scholar
Barth, A.: The infrared absorption of amino acid side chains. Prog. Biophys. Mol. Biol. 141, 74 (2000).Google Scholar
Spanhel, L. and Anderson, M.A.: Semiconductor clusters in the sol-gel process: Quantized aggregation, gelation, and crystal growth in concentrated zinc oxide colloids. J. Am. Chem. Soc. 2826, 113 (1991).Google Scholar
Han, H., Wang, C., Ma, Z., and Su, S.: A facile method to produce highly monodispersed nanospheres of cystine aggregates. Nanotechnology 5163, 17 (2006).Google Scholar
Viswanatha, R., Santra, P.K., and Sarma, D.D.: Self assembly and electronic structure of ZnO nanocrystals. J. Cluster Sci. 389, 20 (2009).Google Scholar
Soares, J.W., Whitten, J.E., Oblas, D.W., and Steeves, D.M.: Novel photoluminescence properties of surface-modified nanocrystalline zinc oxide: Toward a reactive scaffold. Langmuir 371, 24 (2008).Google Scholar
Guo, L., Yang, S., Yang, C., Yu, P., Wang, J., Ge, W., and Wong, G.K.L.: Synthesis and characterization of poly(vinylpyrrolidone)-modified zinc oxide nanoparticles. Chem. Mater. 2268, 12 (2000).Google Scholar
Singh, A.K., Viswanath, V., and Janu, V.C.: Synthesis, effect of capping agents, structural, optical and photoluminescence properties of ZnO nanoparticles. J. Lumin. 874, 129 (2009).Google Scholar
Dijken, A.V., Makkinje, J., and Meijerink, A.: The influence of particle size on the luminescence quantum efficiency of nanocrystalline ZnO particles. J. Lumin. 323, 92 (2001).Google Scholar
Vandijken, A., Meulenkamp, E., Vanmaekelbergh, D., and Meijerink, A.: The luminescence of nanocrystalline ZnO particles: The mechanism of the ultraviolet and visible emission. J. Lumin. 454, 87–89 (2000).Google Scholar
Schmidt-Mende, L. and MacManus-Driscoll, J.L.: ZnO - nanostructures, defects, and devices. Mater. Today 40, 10 (2007).Google Scholar
Buerki-Thurnherr, T., Xiao, L., Diener, L., Arslan, O., Hirsch, C., Maeder-Althaus, X., Grieder, K., Wampfler, B., Mathur, S., Wick, P., and Krug, H.: In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity. Nanotoxicology 7(4), 402–16 (2013).Google Scholar
Tuomela, S., Autio, R., Bürki-Thurnherr, T., Arslan, O., Kunzmann, A., Andersson-Willman, B., Wick, P., Mathur, S., Scheynius, A., Krug, H., Fadeel, B., and Lahesmaa, R.: Gene expression profiling of immune-competent cells exposed to engineered zinc oxide or titanium dioxide nanoparticles: Comprehensive toxicogenomic and bioinformatics approach. PLoS One (2013, in press).Google Scholar
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