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Well-differentiated liposarcoma of the epiglottis

  • A Pajaniappane (a1), J Farzan (a1), D M Green (a2) and M De (a1)

Abstract

Objective:

Liposarcomas of the larynx and its sub-sites are rare. Within this group of tumours, well-differentiated liposarcomas of the epiglottis have been only sporadically reported. In view of its infrequent presentation, difficulty still exists over the diagnosis of this pathological entity, together with uncertainty over its exact accepted management.

Method:

We present the case of a well-differentiated liposarcoma of the epiglottis, and we review the associated English-language literature.

Results:

The reported patient underwent multiple attempts at surgical treatment prior to establishment of a firm diagnosis. In light of the diagnosis and other mitigating factors, a conservative approach was adopted.

Conclusion:

A high index of clinical suspicion and detailed histological analysis are required when encountering a recurrent soft tissue lesion of the larynx. In the presented case, a multidisciplinary approach and conservative management plan were adopted, based on a holistic management approach and a review of the published literature.

Copyright

Corresponding author

Address for correspondence: Mr A Pajaniappane, Department of Otolaryngology/Head and Neck Surgery, Royal Derby Hospital, Uttoxeter Rd, Derby DE22 3AP, UK E-mail: ar25un@hotmail.com

References

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1Wenig, BM, Heffner, DK. Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of the literature. Laryngoscope 1995;105:747–56
2Muddaiah, A, Zaffarullah, W, Tewary, A. Recurrent well-differentiated liposarcoma of the larynx: a case report and review of the literature. Eur Arch Otorhinolaryngol 2010;267:1163–5
3Brauchle, RW, Farhood, AI, Pereira, KD. Well-differentiated liposarcoma of the epiglottis. J Laryngol Otol 2001;115:593–5
4Krausen, AS, Gall, AM, Garza, R, Spector, GJ, Ansel, DG. Liposarcoma of the larynx: a multicentric or a metastatic malignancy. Laryngoscope 1977;87:1116–24
5Mandell, DL, Brandwein, MS, Woo, P, Som, PM, Biller, HF, Urken, ML. Upper aerodigestive tract liposarcoma: report on four cases and literature review. Laryngoscope 1999;109:1245–52
6Narula, A, Jefferis, AF. Squamous cell carcinoma and liposarcoma of the larynx occurring metachronously. J Laryngol Otol 1985;99:509–11
7Kindblom, LG, Angervall, L, Jarlstedt, J. Liposarcoma of the neck: a clinicopathologic study of 4 cases. Cancer 1978;42:774–80
8Wenig, BM, Weiss, SW, Gnepp, DR. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol 1990;14:134–41
9Sommerville, SM, Patton, JT, Luscombe, JC, Mangham, DC, Grimer, RJ. Clinical outcomes of deep atypical lipoma of the extremities. Aust N Z J Surg 2005;75:803–6

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