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Use of narrow-band imaging in detection of nasopharyngeal carcinoma

  • J F Thong (a1), D Loke (a1), R Karumathil Sivasankarannair (a1) and P Mok (a1)



To compare narrow-band images of nasopharyngeal carcinoma with those of normal adenoidal tissue.


Patients with a nasopharyngeal mass were evaluated using both conventional white light and narrow-band light. Biopsies were performed and Epstein–Barr viral serology was tested for all patients.


Thirty consecutive patients were recruited. Twenty-one patients had normal adenoidal tissue and seven had nasopharyngeal carcinoma. One patient with papillary adenocarcinoma was excluded. The features of narrow-band imaging in normal adenoidal tissue were: (1) a regularly arranged follicular pattern, and (2) each ‘follicle’ comprising a pale centre with surrounding dark periphery. The features of narrow-band imaging in nasopharyngeal carcinoma were: (1) absence of surface patterns (n = 7), and/or (2) ‘reverse’, haphazard follicular pattern comprising a dark brown centre and pale periphery (n = 3).


Narrow-band imaging of the surface of adenoidal tissue and nasopharyngeal carcinoma appears to identify distinct, characteristic features as described. Narrow-band imaging may be a useful adjunct in differentiating normal adenoidal tissue from malignancy. Further studies are needed to evaluate its diagnostic accuracy.


Corresponding author

Address for correspondence: Dr Jiun Fong Thong, Department of Otorhinolaryngology-Head and Neck Surgery, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore768828 E-mail:


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Use of narrow-band imaging in detection of nasopharyngeal carcinoma

  • J F Thong (a1), D Loke (a1), R Karumathil Sivasankarannair (a1) and P Mok (a1)


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