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A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy

Published online by Cambridge University Press:  29 June 2022

R Swaminathan Open the ORCID record for R Swaminathan [Opens in a new window] ,
S Rosa Opatha ,
Z Mughal Open the ORCID record for Z Mughal [Opens in a new window]  and
S Prasad
R Swaminathan*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Warwick Hospital, UK
S Rosa Opatha
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Warwick Hospital, UK
Z Mughal
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Queen Elizabeth Hospital, Birmingham, UK
S Prasad
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospitals Coventry & Warwickshire NHS Trust, UK
*
Author for correspondence: Dr R Swaminathan, Department of Otorhinolaryngology and Head and Neck Surgery, Warwick Hospital, Lakin Road, Warwick, CV34 5BW, UK E-mail: Ramanathan.Swaminathan@swft.nhs.uk Fax: +44 1926 482 607
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Abstract

Objective

Laryngeal cancer is the second most prevalent head and neck malignancy in the USA. With recent advances in technology, this procedure is increasingly performed under local anaesthesia. This study aimed to identify the efficacy, safety and cost-effectiveness of laryngeal biopsy in out-patients by conducting a systematic review.

Method

A literature search was conducted using PubMed, Medline, Google Scholar and Embase over a 20-year period. Inclusion criteria were: studies performed on out-patient diagnostic biopsy procedures of the larynx. Exclusion criteria included all therapeutic procedures. The outcome measures were sensitivity and specificity, complication rate and cost-savings.

Results

Thirty-five studies were included in the analysis. The sensitivity and specificity varied from 60 to 100 per cent with a low complication rate and cost savings.

Conclusion

Office-based laryngeal biopsies are increasingly used in the diagnosis of laryngeal cancers, resulting in earlier diagnosis and commencement of treatment. The barrier to undertaking this procedure is low sensitivity.

Keywords

Laryngeal BiopsyOutpatientsOffice
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 9 , September 2023 , pp. 946 - 952
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr R Swaminathan takes responsibility for the integrity of the content of the paper

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