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Surgical management of amiodarone-induced thyrotoxicosis in a patient with Eisenmenger's syndrome: literature review and case report

Published online by Cambridge University Press:  02 December 2008

R Pratap ,
A Qayyum ,
N Ahmad  and
P Jani
R Pratap
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital, Cambridge, UK
A Qayyum*
Affiliation:
Department of Otolaryngology, Ipswich Hospital, Cambridge, UK
N Ahmad
Affiliation:
Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK
P Jani
Affiliation:
Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK
*
Address for correspondence: Mr Asad Qayyum, 16 Lavendon House, 8 Paveley Street, London NW8 8TJ, UK. E-mail: asadqayyum@doctors.net.uk
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Abstract

Objective:

We present a patient with a rare combination of amiodarone-induced thyrotoxicosis and Eisenmenger's syndrome.

Method:

Case report and review of the world literature regarding the morbidity and mortality of surgical management of amiodarone-induced thyrotoxicosis and the potential hazards of non-cardiac surgery in patients with Eisenmenger's syndrome.

Results:

Failure of maximal medical therapy necessitated surgical management to treat amiodarone-induced thyrotoxicosis which, in this particular patient, carried significant risks. Total thyroidectomy was performed leading to rapid resolution of thyrotoxicosis, and the patient made an uncomplicated recovery. We present this case because of its rarity and the potentially hazardous nature of surgical intervention in patients with Eisenmenger's syndrome. The pathogenesis of amiodarone-induced thyrotoxicosis and the differing approaches of medical and surgical management are discussed.

Conclusion:

Based on our findings, we propose that surgical management should be considered earlier in the treatment algorithm (or possibly as first-line therapy) for amiodarone-induced thyrotoxicosis.

Keywords

AmiodaroneThyrotoxicosisThyroid SurgeryEisenmenger's Syndrome
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 11 , November 2009 , pp. 1276 - 1279
Copyright
Copyright © JLO (1984) Limited 2009

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