Skip to main content Accessibility help

Sudden sensorineural hearing loss is associated with chronic rhinosinusitis: population-based study

  • S H Hung (a1), H C Lin (a2), L T Kao (a3), C S Wu (a4) and S D Chung (a1) (a2) (a5) (a6)...



This study aimed to evaluate the association of chronic rhinosinusitis with sudden sensorineural hearing loss using a population-based database.


Sampled subject data were obtained from the Taiwan Longitudinal Health Insurance Database 2000. A total of 3325 patients with sudden sensorineural hearing loss were identified and 9975 controls were randomly selected. A conditional logistic regression was used to calculate the odds ratio for having been previously diagnosed with chronic rhinosinusitis, for cases and controls.

Results and conclusion:

The adjusted odds ratio of having prior chronic rhinosinusitis among cases compared to controls was 1.36 (95 per cent confidence interval = 1.16–1.60). The significant relationship between sudden sensorineural hearing loss and chronic rhinosinusitis was most pronounced among those patients aged 44 years or less (compared to controls) (odds ratio = 2.18; 95 per cent confidence interval = 1.63–2.92). However, the significant relationship between sudden sensorineural hearing loss and prior chronic rhinosinusitis was not sustained for patients older than 60 years compared to controls.


Corresponding author

Address for correspondence: Dr Shiu-Dong Chung, Department of Surgery, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya South Rd, Banciao District, New Taipei City 220, Taiwan E-mail:


Hide All
1 Byl, FM Jr. Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope 1984;94:647–61
2 Hughes, GB, Freedman, MA, Haberkamp, TJ, Guay, ME. Sudden sensorineural hearing loss. Otolaryngol Clin North Am 1996;29:393405
3 Simmons, F. Theory of membrane breaks in sudden hearing loss. Arch Otolaryngol 1968;88:41–8
4 Kuhn, M, Heman-Ackah, SE, Shaikh, JA, Roehm, PC. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif 2011;15:91105
5 Park, JH, Park, SJ, Kim, YH, Park, MH. Sensorineural hearing loss: a complication of acute otitis media in adults. Eur Arch Otorhinolaryngol 2014;271:1879–84
6 Van, Cauwenberge P, Watelet, JB. Epidemiology of chronic rhinosinusitis. Thorax 2000;55:S20–1
7 Sultész, M, Csákányi, Z, Majoros, T, Farkas, Z, Katona, G. Acute bacterial rhinosinusitis and its complications in our pediatric otolaryngological department between 1997 and 2006. Int J Pediatr Otorhinolaryngol 2009;73:1507–12
8 Hung, SH, Chen, PY, Lin, HC, Ting, J, Chung, SD. Association of rhinosinusitis with nasopharyngeal carcinoma: a population-based study. Laryngoscope 2014;124:1515–20
9 Chen, YC, Yeh, HY, Wu, JC. Taiwan's National Health Insurance Research Database: administrative health care database as study object in bibliometrics. Scientometrics 2011;86:365–80
10 Vasama, JP, Linthicum, FH Jr. Idiopathic sudden sensorineural hearing loss: temporal bone histopathologic study. Ann Otol Rhinol Laryngol 2000;109:527–32
11 Wilson, WR. The relationship of the herpesvirus family to sudden hearing loss: a prospective clinical study and literature review. Laryngoscope 1986;96:870–7
12 Oyer, SL, Mulligan, JK, Psaltis, AJ, Henriquez, OA, Schlosser, RJ. Cytokine correlation between sinus tissue and nasal secretions among chronic rhinosinusitis and controls. Laryngoscope 2013;123:E728
13 Demirhan, E, Eskut, NP, Zorlu, Y, Cukurova, I, Tuna, G, Kirkali, FG. Blood levels of TNF-alpha, IL-10, and IL-12 in idiopathic sudden sensorineural hearing loss. Laryngoscope 2013;123:1778–81
14 Braskett, M, Riedl, MA. Novel antioxidant approaches to the treatment of upper airway inflammation. Curr Opin Allergy Clin Immunol 2010;10:3441
15 Jardeleza, C, Jones, D, Baker, L, Miljkovic, D, Boase, S, Tan, NC et al. Gene expression differences in nitric oxide and reactive oxygen species regulation point to an altered innate immune response in chronic rhinosinusitis. Int Forum Allergy Rhinol 2013;3:193–8
16 Rewerska, A, Pawelczyk, M, Rajkowska, E, Politanski, P, Sliwinska-Kowalska, M. Evaluating D-methionine dose to attenuate oxidative stress-mediated hearing loss following overexposure to noise. Eur Arch Otorhinolaryngol 2013;270:1513–20
17 Capaccio, P, Pignataro, L, Gaini, LM, Sigismund, PE, Novembrino, C, De, Giuseppe R et al. Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2012;269:449–53
18 Wu, D, Meydani, SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol 2008;84:900–14
19 Escada, PA, Capucho, C, Madeira da Silva, JF. Sudden sensorineural hearing loss following intramuscular administration of penicillin. J Laryngol Otol 2004;118:143–5
20 Schweitzer, VG, Olson, NR. Ototoxic effect of erythromycin therapy. Arch Otorhinolaryngol 1984;110:258–60



Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed