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Squamous cell hyperplasia of the larynx

A clinical follow-up study

Published online by Cambridge University Press:  29 June 2007

P. Olde Kalter ,
H. Lubsen ,
J. F. M. Delemarre  and
G. B. Snow
P. Olde Kalter*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
H. Lubsen
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
J. F. M. Delemarre
Affiliation:
Department of Pathology, Antoni van Leeuwenhoekhuis (The Netherlands Cancer Institute), Amsterdam, The Netherlands.
G. B. Snow
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
*
P. OldeKalter, M.D., Department of Otolaryngology, Free University Hospital, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
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Abstract

According to Kleinsasser's classification 200 patients with squamous cell hyperplasia, seen between 1963–1981, were reviewed histologically. The untreated patients (47 per cent) have been analysed for the incidence of malignant change and the patients with Class III lesions (carcinoma in situ) who were treated, were analysed for response to treatment. The mean follow-up period was 8.4 years. Only two of the 38 initially untreated patients of Class I (simple squamous cell hyperplasia) developed an invasive carcinoma. In Class II (hyperplasia with atypia), of 62 patients who were not treated initially, 17 developed a laryngeal squamous cell carcinoma later. Only six patients of Class III did not receive any treatment initially, and one of these progressed to invasive carcinoma. Almost all other patients with carcinoma in situ (Class III) were irradiated. In these patients no evidence of local recurrence was found.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 6 , June 1987 , pp. 579 - 588
Copyright
Copyright © JLO (1984) Limited 1987

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