Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-25T11:17:38.967Z Has data issue: false hasContentIssue false
  • English
  • Français

Second primary cancer of the larynx in patients with lung cancer

Published online by Cambridge University Press:  29 June 2007

Yoav P. Talmi ,
Lev Bedrin ,
Alexander Waller ,
Zeev Horowitz ,
Yair Skurnik ,
Abraham Adunski  and
Jona Kronenberg
Yoav P. Talmi*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Lev Bedrin
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Alexander Waller
Affiliation:
Tel Hashomer Hospice (Israeli Cancer Association), The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Zeev Horowitz
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Yair Skurnik
Affiliation:
General Medicine B, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Abraham Adunski
Affiliation:
Geriatric Department, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
Jona Kronenberg
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, The Chaim Sheba Medical Center and the Tel-Aviv University Sackler School of Medicine, Tel Hashomer 52621, Israel.
*
Address for correspondence: Yoav P. Talmi, M.D., Department of Otolaryngology – Head and Neck Surgery, The Chain Sheba Medical Center, Tel Hashomer 52621, Israel.
Get access Rights & Permissions [Opens in a new window]

Abstract

Synchronous or metachronous second primary malignancies of the lung are sometimes encountered in patients with laryngeal cancer while the occurrence of a laryngeal second primary following cancer of the lung is rare.

A two-armed study was conducted. A prospective arm in which the larynges of 56 terminal lung cancer patients were examined, and a retrospective arm incorporating both a chart study of 126 terminal head and neck cancer patients (HNCP) and a computerized search of all hospital records of patients with laryngeal and lung cancers. No laryngeal malignancy was found in the lung cancer patients' group and no antedating pulmonary malignancy was recorded in the terminal HNCP. The computerized search of 1778 lung cancer patients and 213 laryngeal cancer patients also failed to demonstrate cases where the former preceded the latter.

In conclusion. No second primary of the larynx was found in lung cancer patients. These results compare with reports of large databases where cancer of the larynx was found in a negligible percentage of lung cancer survivors and theories explaining this are discussed.

Keywords

Lung neoplasmsLaryngeal neoplasmsNeoplasmssecond primary
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 3 , March 1998 , pp. 252 - 257
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bedi, G. C., Westra, W. H., Gabrielson, E., Koch, W., Sidransky, D. (1996) Multiple head and neck tumours: Evidence for a common clonal origin. Cancer Research 56: 2484–2487.Google ScholarPubMed
Boice, J. D., Fraumeni, J. F. (1985) Second cancer following cancer of the respiratory system in Connecticut. National Cancer Institute Monographs 68: 83–86.Google ScholarPubMed
Cahan, W. G., Butler, F. S. (1950) Multiple cancers: Primary in the lung and other sites. Journal of Thoracic Surgery 20: 335–348.CrossRefGoogle ScholarPubMed
Cahan, W. G., Montemayor, P. B. (1962) Cancer of the larynx and lung in the same patient. Thoracic Cardiovascular Surgeon 44: 309–320.CrossRefGoogle ScholarPubMed
Califano, J., van der Riet, P., Westra, W. H., Nawroz, H., Clayman, G., Piantadosi, S., Corio, R., Lee, D., Greenberg, B., Koch, W., Sidransky, D. (1996) Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Research 56: 2488–2492.Google ScholarPubMed
Carey, T. E. (1996) Field cancerization: Are multiple primary cancers monoclonal or polyclonal? Annals of Medicine 28: 183–188.CrossRefGoogle ScholarPubMed
Day, G. L., Blot, W. J., Shore, R. E., McLaughlin, J. K., Austin, D. F., Greenberg, R. S., Liff, J. M., Preston-Martin, S., Sarkar, S., Schoenbeg, J. B., Fraumeni, J. F. (1994) Second cancers following oral and pharyngeal cancers: role of tobacco and alcohol. Journal of the National Cancer Institute 86: 131–137.CrossRefGoogle ScholarPubMed
Deviri, E., Bartal, A., Goldsher, M., Eliachar, I., Steinitz, R., Robinson, E. (1982) Occurrence of additional primary neoplasms in patients with laryngeal carcinoma in Israel (1960–1976). Annals of Otology, Rhinology and Laryngology 91: 261–265.CrossRefGoogle ScholarPubMed
Haughey, B. H., Gates, G. A., Arfken, C. L., Harvey, J. (1992) Meta-analysis of second malignant tumours in head and neck cancer: the case for an endoscopic screening protocol. Annals of Otology, Rhinology and Laryngology 101: 105–112.CrossRefGoogle ScholarPubMed
Heyne, K. H., Lippman, S. M., Lee, J. J., Lee, J. S., Hong, W. K. (1992) The incidence of second primary tumours in long-term survivors of small-cell lung cancer. Journal of Clinical Oncology 10: 1519–1524.CrossRefGoogle ScholarPubMed
Hong, W. K., Lippman, S. M., Itri, L. M., Karp, D. D., Lee, J. S., Byers, R. M., Schantz, S. P., Kramer, A. M., Lotan, R., Peters, L. J., Dimery, I. W., Brown, B. W., Goepfert, H. (1990) Prevention of second primary tumours with isotretinoin in squamous-cell carcinoma of the head and neck. New England Journal of Medicine 323: 795–801.CrossRefGoogle ScholarPubMed
Hordijk, G. J., Bruggink, T., Ravasz, L. A. (1989) Panendoscopy: a valuable procedure? Otolaryngology – Head and Neck Surgery 101: 426–428.CrossRefGoogle ScholarPubMed
Johnson, B. E., Linnoila, R. I., Williams, J. P., Venzon, D. J., Okunieff, P., Anderson, G. B., Richardson, G. E. (1995) Risk of second aerodigestive cancers increases in patients who survive free of small-cell lung cancer for more than 2 years. Journal of Clinical Oncology 13: 101–111.CrossRefGoogle Scholar
Lyons, M. F., Redmond, J.Illrd, , Covelli, H. (1986) Multiple primary neoplasia of the head and neck and lung. The changing histopathology. Cancer 57: 2193–2197.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Marks, P. H., Schechter, F. G. (1982) Multiple primary carcinomas of the head, neck, and lung. Annals of Thoracic Surgery 33: 324–332.CrossRefGoogle ScholarPubMed
Massard, G., Roeslin, N., Jung, G. M., Dumont, P., Wihlm, J. M., Morand, G. (1993) Bronchogenic cancer associated with head and neck tumours. Survival analysis of 194 patients. Journal of Thoracic Cardiovascular Surgery 106: 218–227.CrossRefGoogle ScholarPubMed
McGarry, G. W., Mackenzie, E. K. (1990) Second primary tumours of the larynx following bronchial carcinoma. Journal of Laryngology and Otology 104: 629–630.CrossRefGoogle ScholarPubMed
McGuirt, W. F. (1982) Panendoscopy as a screening examination for simultaneous primary tumours in head and neck cancer: a prospective sequential study and review of the literature. Laryngoscope 92: 569–576.CrossRefGoogle ScholarPubMed
McGuirt, W. F., Matthews, B., Koufman, J. A. (1982) Multiple simultaneous tumours in patients with head and neck cancer: a prospective, sequential panendoscopic study. Cancer 50: 1195–1199.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Mulvihill, J. J., McKeen, E. A. (1977) Discussion: genetics of multiple primary tumours: a clinical etiologic approach illustrated by three patients. Cancer 40: 1867–1871.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Olsen, J. H. (1985) Second cancer following cancer of the respiratory system in Denmark, 1943–80. National Cancer Institute Monograph 68: 309–324.Google ScholarPubMed
Panosetti, E., Luboinski, B., Mamelle, G., Richard, J. M. (1989) Multiple synchronous and metachronous cancers of the upper aerodigestive tract: a nine-year study. Laryngoscope 99: 1267–1273.CrossRefGoogle ScholarPubMed
Pastorino, U., Soresi, E., Clerici, M., Chiesa, G., Belloni, P. A., Ongari, M., Valente, M., Ravasi, G. (1988) Lung cancer chemoprevention with retinol palmitate. Preliminary data from a randomized trial on stage la non small-cell lung cancer. Acta Oncologica 27: 773–782.CrossRefGoogle Scholar
Pastorino, U., Infante, M., Maioli, M., Chiesa, G., Buyse, M., Firket, P., Rosmentz, N., Clerici, M., Soresi, E., Valente, M., Belloni, P. A., Ravasi, G. (1993a) Adjuvant treatment of stage I lung cancer with high-dose vitamin A. Journal of Clinical Oncology 11: 1216–1222.CrossRefGoogle Scholar
Pastorino, U., Sozzi, G., Miozzo, M., Tagliabue, E., Pilotti, S., Pierotti, M. A. (1993b) Genetic changes in lung cancer. Journal of Cell Biochemistry Suppl 17F: 237–248.CrossRefGoogle ScholarPubMed
Pedersen-Bjergaard, J., Osterlind, K., Hansen, M., Philip, P., Pedersen, A. G., Hansen, H. H. (1985) Acute nonlympho-cytic leukemia, preleukemia and solid tumours following intensive chemotherapy of small cell carcinoma of the lung. Blood 66: 1393–1397.CrossRefGoogle ScholarPubMed
Rubenstein, A. S., Graham, J., Barnes, N. (1958) Associated carcinoma of the larynx and lung. Archives of Otolaryngology 68: 710–714.CrossRefGoogle ScholarPubMed
Sagman, U., Lishner, M., Maki, E., Shepherd, F. A., Haddad, R., Evans, W. K., DeBoer, G., Payne, D., Pringle, J. F., Yeoh, J. L., Ginsberg, R., Feld, R. (1992) Second primary malignancies following diagnosis of small-cell lung cancer. Journal Clinical Oncology 10: 1525–1533.CrossRefGoogle ScholarPubMed
Salminen, E., Pukkala, E., Teppo, L., Pyrhonen, S. (1995) Risk of second cancers among lung cancer patients. Acta Oncologica 34: 165–169.CrossRefGoogle ScholarPubMed
Schantz, S. P., Spitz, M. R., Hsu, T.C. (1990) Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies. Journal National of the Cancer Institute 82: 1773–1775.CrossRefGoogle ScholarPubMed
Shields, T. W., Robinette, C. D. (1973) Long term survivors after resection of bronchial carcinoma. Surgery Gynecology Obstetrics 136: 759–762.Google ScholarPubMed
Silvestri, F., Bussani, R., Cosatti, C., Bosatra, A. (1994) High relative risk of a second pulmonary cancer in patients affected by laryngeal cancer: differences by specific site of occurrence and lung cancer histotype. Laryngoscope 104: 222–225.CrossRefGoogle ScholarPubMed
Slaughter, D. P., Southwick, H. W., Smejkal, W. (1953) ‘Field cancerization’ in oral stratified squamous epithelium. Cancer 6: 963–968.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Souhami, R. L., Law, K. (1990) Longevity in small cell lung cancer. A report to the Lung Cancer Subcommittee of the United Kingdom Coordinating Committee for Cancer Research. British Journal of Cancer 61: 584–589.CrossRefGoogle Scholar
Spitz, M. R., Hoque, A., Trizna, Z., Schantz, S. P., Amos, C. I., King, T. M., Bondy, M. L., Hong, W. K., Hsu, T. S. (1994) Mutagen sensitivity as a risk factor for second malignant tumours following malignancies of the upper aerodigestive tract. Journal of the National Cancer Institute 86: 1681–1684.CrossRefGoogle ScholarPubMed
Strigenz, M. A., Toohill, R. J., Grossman, T. W. (1987) Association of laryngeal and pulmonary malignancies: a continuing challenge. Annals of Otology, Rhinology and Laryngology 96: 621–624.CrossRefGoogle ScholarPubMed
Talmi, Y. P., Roth, Y., Waller, A., Chesnin, V., Adunski, A., Lander, M. I., Kronenberg, J. (1995) Care of the terminal head and neck cancer patient in the hospice setting. Laryngoscope 105: 315–318.CrossRefGoogle ScholarPubMed
Talmi, Y. P., Cotlear, D., Waller, A., Horowitz, Z., Adunski, A., Kronenberg, J. (1997) Distant metastases in terminal head and neck cancer patients. Journal of Laryngology and Otology 111: 454–458.CrossRefGoogle ScholarPubMed
Temeck, B. K., Flehinger, B. J., Martini, N. (1984) A retrospective analysis of 10-year survivors from carcinoma of the lung. Cancer 53: 1405–1408.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Teppo, L., Pukkala, E., Saxen, E. (1985) Multiple cancer – an epidemiologic exercise in Finland. Journal of the National Cancer Institute 75: 207–217.Google ScholarPubMed
Thomas, P. A. Jr., Rubinstein, L. (1993) Malignant disease appearing late after operation for Tl NO non-small-cell lung cancer. The Lung Cancer Study Group. Journal of Thoracic and Cardiovascular Surgery 106: 1053–1058.CrossRefGoogle Scholar
van Bodegom, P. C., Wagenaar, S. S., Corrin, B., Baak, J. P., Berkel, J., Vanderschueren, R. G. (1989) Second primary lung cancer: importance of long-term follow-up. Thorax 44: 788–793.CrossRefGoogle ScholarPubMed
Volk, S. A., Mansour, R. F., Gandara, D. R., Redmond, J. III (1984) Morbidity in long-term survivors of small cell carcinoma of the lung. Cancer 54: 25–27.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Worsham, M. J., Wolman, S. R., Carey, T. E., Zarbo, R. J., Benninger, M. S., Van Dyke, D. L. (1995) Common clonal origin of synchronous primary head and neck squamous cell carcinomas: analysis by tumour karyotypes and fluorescence in situ hybridization. Human Pathology 26: 251–261.CrossRefGoogle ScholarPubMed
Yellin, A., Hill, L. R., Benfield, J. R. (1986) Bronchogenic carcinoma associated with upper aerodigestive cancers. Journal of Thoracic and Cardiovascular Surgery 91: 674–683.CrossRefGoogle ScholarPubMed