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Response to docetaxel and cisplatin induction chemotherapy of locally advanced head and neck squamous cell carcinoma: a multicenter, non-comparative, open-label interventional pilot study

  • V Noronha (a1), C Goswami (a2), S Patil (a3), A Joshi (a1), V M Patil (a1), V Murthy (a4), S Arya (a5), S Juvekar (a5), S Goud (a3) and K Prabhash (a3)...

Abstract

Background:

Docetaxel, cisplatin plus 5-fluorouracil is an efficacious induction regimen but is more toxic than cisplatin plus 5-fluorouracil. This study aimed to determine whether docetaxel and cisplatin without 5-fluorouracil maintains efficacy while decreasing toxicity.

Methods:

A multicenter non-comparative pilot study of locally advanced squamous cell carcinoma of the head and neck was performed. Patients received primary therapy comprising three cycles of 75 mg/m2 docetaxel and 75 mg/m2 cisplatin followed by concurrent chemoradiotherapy. The primary endpoint was the response rate to the docetaxel and cisplatin induction regimen.

Results:

A total of 26 patients were enrolled: of these, 23 (88.5 per cent) received all three docetaxel and cisplatin cycles. Common grade 3–4 adverse events were febrile neutropenia (19.2 per cent of patients), diarrhoea (19.2 per cent) and non-neutropenic infection (15.4 per cent). The overall response rate to docetaxel and cisplatin induction chemotherapy was 65.4 per cent. A total of 23 patients (88.5 per cent) subsequently received chemoradiotherapy with a median radiotherapy dose of 70 Gy. The response rate to chemoradiotherapy was 73 per cent. At a median follow up of 44 months, the 3-year progression-free survival and overall survival rates were 62 per cent and 69 per cent, respectively.

Conclusion:

Docetaxel and cisplatin induction chemotherapy is a feasible induction regimen with comparable efficacy to docetaxel, cisplatin and 5-fluorouracil induction chemotherapy.

Copyright

Corresponding author

Address for correspondence: Dr K Prabhash, Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai 400012, Maharashtra, India E-mail: kumarprabhashtmh@gmail.com

References

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Keywords

Response to docetaxel and cisplatin induction chemotherapy of locally advanced head and neck squamous cell carcinoma: a multicenter, non-comparative, open-label interventional pilot study

  • V Noronha (a1), C Goswami (a2), S Patil (a3), A Joshi (a1), V M Patil (a1), V Murthy (a4), S Arya (a5), S Juvekar (a5), S Goud (a3) and K Prabhash (a3)...

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