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Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients

  • H S Lee (a1), C Park (a1), S W Kim (a1), J W Song (a1), B K Chun (a2), T J Park (a3), J C Hong (a4) and K D Lee (a1)...

Abstract

Objective:

This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients.

Method:

A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted.

Results:

A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733).

Conclusion:

Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.

Copyright

Corresponding author

Address for correspondence: Dr K D Lee, Department of Otolaryngology, Kosin University Gospel Hospital Am-Nam Dong 34, Seo-Gu, Busan 602–702, South Korea Fax: +82 51 245 8539 E-mail: kdlee59@gmail.com

References

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