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Platelet-rich plasma in otolaryngology

  • M Stavrakas (a1), P D Karkos (a1) (a2), K Markou (a1) and N Grigoriadis (a3) (a4)



Platelet-rich plasma is a novel material that is being used more frequently in many surgical specialties.


A literature review on the current and potential uses of platelet-rich plasma in otolaryngology was performed.


There is limited evidence on the use of platelet-rich plasma in otolaryngology compared with other specialties: only 11 studies on various subspecialties (otology, rhinology and laryngology) were included in the final review.


Based on the limited number of studies, we cannot draw safe conclusions about the value of platelet-rich plasma in otolaryngology. Nevertheless, the available literature suggests that platelet-rich plasma holds promise for future research and may have a number of clinical applications.


Corresponding author

Address for correspondence: Mr M Stavrakas, Department of Otolaryngology, AHEPA University Hospital, S. Kiriakidi 1, Thessaloniki 54621, Greece E-mail:


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1 Gopalakrishnan, S, Venkatasamy, P, Vivekanandamurthy, K. A study on efficacy of autologous platelet rich plasma in myringoplasty. Online J Otolaryngol 2013;3:3651
2 Sclafani, AP, Azzi, J. Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature. Aesthetic Plast Surg 2015;39:495505
3 Pomerantz, J, Dutton, JM. Platelet gel for endoscopic sinus surgery. Ann Otol Rhinol Laryngol 2005;114:699704
4 Rice, DH. Platelet-rich plasma in endoscopic sinus surgery. Ear Nose Throat J 2006;85:516
5 Sidman, JD, Lander, TA, Finkelstein, M. Platelet-rich plasma for pediatric tonsillectomy patients. Laryngoscope 2008;118:1765–7
6 Erkilet, E, Koyuncu, M, Atmaca, S, Yarim, M. Platelet-rich plasma improves healing of tympanic membrane perforations: experimental study. J Laryngol Otol 2009;123:482
7 Cho, HH, Jang, S, Lee, SC, Jeong, HS, Park, JS, Han, JY et al. Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model. Laryngoscope 2010;120:907–13
8 Navarrete Álvaro, ML, Ortiz, N, Rodriguez, L, Boemo, R, Fuentes, J, Mateo, A et al. Pilot study on the efficiency of the biostimulation with autologous plasma rich in platelet growth factors in otorhinolaryngology: otologic surgery (tympanoplasty type I). ISRN Surg 2011:14
9 Salaheldin, AH, Hussein, A. Effect of platelet-rich plasma on nasal mucociliary clearance after submucous diathermy of inferior turbinate. EJENTAS 2012;13:71–5
10 Friji, M, Gopalakrishnan, S, Verma, S, Parida, P, Mohapatra, D. New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: our experience. Clin Otolaryngol 2014;39:289–92
11 Woo, SH, Jeong, H-S, Kim, JP, Koh, E-H, Lee, SU, Jin, SM et al. Favorable vocal fold wound healing induced by platelet-rich plasma injection. Clin Exp Otorhinolaryngol 2014;7:4752
12 Cobden, SB, Oztürk, K, Duman, S, Esen, H, Aktan, TM, Avunduk, MC et al. Treatment of acute vocal fold injury with platelet-rich plasma. J Voice 2015; doi: 10.1016/j.jvoice.2015.07.012


Platelet-rich plasma in otolaryngology

  • M Stavrakas (a1), P D Karkos (a1) (a2), K Markou (a1) and N Grigoriadis (a3) (a4)


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