Hostname: page-component-7479d7b7d-qlrfm Total loading time: 0 Render date: 2024-07-12T10:05:01.506Z Has data issue: false hasContentIssue false
  • English
  • Français

Pathology of the otic capsule

Published online by Cambridge University Press:  29 June 2007

C. M. Milroy  and
L. Michaels
C. M. Milroy*
Affiliation:
London
L. Michaels
Affiliation:
London
*
Dr C. M. Milroy, Department of Histopathology, University College and Middlesex School of Medicine, Rockefeller Building, University Street, London WC1E 6JJ.
Get access Rights & Permissions [Opens in a new window]

Abstract

The otic capsule is unique in retaining calcified cartilage, known as globuli interossei, throughout life and shows changes consequently, which are peculiar to it. In Paget's disease of bone, the otic capsule appears resistant to involvement and this occurs with extensive disease at a late stage. In contrast, otosclerosis is a new bone formation of unknown cause that is limited to the otic capsule. In osteogenesis imperfecta, the poor formation of collagen leads to abnormally thin bony trabeculae with a poorly formed otic capsule. In osteopetrosis, the otic capsule is greatly expanded by increased globuli interossei, as a result of defective osteoclast function. When fractured the middle layer of the otic capsule does not form callus, but heals by fibrosis.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 2 , February 1990 , pp. 83 - 90
Copyright
Copyright © JLO (1984) Limited 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Altmann, F. (1933) Zur Anatomie und Klinik der Schläfenben-beinveränderungen bei der Marmorknochenkrankheit (Albers-Schönberg). Monatsschrift für Ohrenheilkunde und Laryngorhinologie, 67: 1281–1308.Google Scholar
Altmann, F. and Kornfield, M. (1967) Osteogenesis imperfecta and otosclerosis: New investigations. Annals of Otology, Rhinology and laryngology, 76: 89–104.CrossRefGoogle ScholarPubMed
Anorld, W. and Friedmann, I. (1988) Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology? Journal of Laryngology and Otology, 102: 865–871.Google Scholar
Arslan, M. and Ricci, V. (1963) Histochemical investigations of otosclerosis with special regard to collagen disease. Journal of Laryngology and Otology, 77: 365–373.CrossRefGoogle Scholar
Ballet, J. P., Grisvelli, C., Courtris, G. Milhaud, G. and Marteaux, P. (1977) Bone marrow transplantation in osteopetrosis. Lancet, II: 1137–1139.Google Scholar
Coccia, P. F., Krivit, K., Cervenka, J., Clawson, C., Kersey, J. H., Kim, T. H., Nesbit, M. E., Ramsay, N. K. C., Warkentin, P. I., Teitalbaun, S. C., Kahn, A. J. and Brown, D. M. (1980) Successful bone marrow transplantation for infantile malignant osteopetrosis. New England Journal of Medicine, 302: 701–708.CrossRefGoogle ScholarPubMed
Davis, D. G. (1968) Paget's disease of the temporal bone. Ada Otolaryngoligica, (Supplement 242): 1–47.Google Scholar
Friedmann, I. (1974 a) Pathology of the ear. Blackwell, Oxford, 502–504.Google Scholar
Friedmann, I. (1974 b) Pathology of the ear. Blackwell, Oxford, 452.Google Scholar
Gussen, R. (1970) Early Paget's disease of the labyrinthine capsule. Archives of Otolaryngology, 91: 341–345.CrossRefGoogle ScholarPubMed
Hawke, M., Jahn, A. F. and Bailey, D. (1981) Osteopetrosis of the temporal bone. Archives of Otolaryngology, 107: 278–282.CrossRefGoogle ScholarPubMed
Igarishi, M., King, A. I., Schwenzfeier, C. W., Wantanabe, T. and Alford, B. R. (1980) Inner ear pathology in osteogenesis imperfecta congenita. Journal of Laryngology and Otology, 94: 697–705.CrossRefGoogle Scholar
Jahn, A. F. (1987) Bone physiology. In: Physiology of the Ear, eds. Jahn, A. F. and Santos-Sacchi, J. Raven New York, pp. 145–158.Google Scholar
Lindsay, J. R. and Lehman, R. H. (1969) Histopathology of the temporal bone in advanced Paget's disease. Laryngoscope, 79: 213–227.CrossRefGoogle ScholarPubMed
Marks, S. C. (1973) Pathogenesis of osteopetrosis in the ia rat; reduced bone resorption due to reduced osteoclastic function. American Journal of Anatomy, 138: 165–190.Google Scholar
Michaels, L. and Wells, M. (1980) Squamous carcinoma of the middle ear. Clinical Otolaryngology, 5: 235–248.CrossRefGoogle ScholarPubMed
Michaels, L., Wells, M. and Frohlich, A. (1983) A new technique for the study of temporal bone pathology. Clinical Otolaryngology, 8: 77–85.CrossRefGoogle Scholar
Michaels, L. (1987) Ear, nose and throat histopathology. Springer-Verlag, London, pp. 117–120.CrossRefGoogle Scholar
Milroy, C. M. and Michaels, L. (in press) Temporal bone pathology of adult type osteopetrosis. Archives of Otolaryngology—Head and neck Surgery.Google Scholar
Myers, E. N. and Stool, S. (1969) The temporal bone in osteopetrosis. Archives of Otolaryngology, 89: 460–469.Google Scholar
Nager, G. T. (1975) Paget's disease of the temporal bone. Annals of Otology, Rhinology and Laryngology, 84 (supplement 22): 1–32.CrossRefGoogle ScholarPubMed
Nager, G. T., Kennedy, D. W. and Kopstein, E. (1982) Fibrous dysplasia: a review of the disease and its manifestations in the temporal bone. Annals of Otology, Rhinology and Laryngology, 91 (supplement 92): 5–51.Google Scholar
Nager, G. T. (1986) Osteogenesis imperfecta of the temporal bone and its relation to otosclerosis. Annals of Otolaryngology, Rhinology and Laryngology, 97: 585–593.CrossRefGoogle Scholar
Page, L. K. (1972) The concurrence of osteitis deformans and acoustic neurinoma. American Journal of Medicine, 53: 697–700.Google Scholar
Proops, D., Bayley, D. and Hawke, M. (1985) Paget's disease and the temporal bone—a clinical and histopathological review of six temporal bones. Journal of Otolaryngology, 14: 20–29.Google ScholarPubMed
Revell, P. A. (1986) Pathology of Bone. Springer-Verlag, London. 1986, pp. 50–55.CrossRefGoogle Scholar
Schuknecht, H. (1967) Pathology of sensori-neural deafness of genetic origin. In: Deafness in childhood, eds McConnell, F., Ward, P. H. and Vanderbilt, U. P., Nashville, pp. 79–80.Google Scholar
Schuknecht, H. F. (1983) Cochlear otosclerosis—An intractable absurdity. Journal of Laryngology and Otology, Supplement 8: 81–83.Google Scholar
Suga, F. and Lindsay, J. R. (1976) Temporal bone histopathology of osteopetrosis. Annals of Otology, Rhinology and Laryngology, 85: 15–24.Google Scholar
Walker, D. G. (1973) Osteopetrosis—cured by temorary parabiosis. Science, 180: 874–875.CrossRefGoogle Scholar
Yoo, T. Z., Shea, J. J. and Floyd, R. A. (1987) Endochondral cartilage rests collagen induced auto-immunity. American Journal of Otolaryngology, 8: 317–324.CrossRefGoogle Scholar
Zajtchuk, J. T. and Lindsay, J. R. (1975) Osteogenesis imperfecta congenita and tarda: A temporal bone report. Annals of Otology, Rhinology and Laryngology, 84: 350–358.CrossRefGoogle Scholar