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Olfactory neural tumours—the role of external beam radiotherapy

  • N. J. Slevin (a1), C. J. R. Irwin (a1), S. S. Banerjee (a2), N. K. Gupta (a1) and W. T. Farrington (a3)...

Abstract

Olfactory neuroblastoma is an uncommon tumour arising in the nasal cavity or paranasal sinuses. We report the management of nine cases treated with external beam radiotherapy subsequent to sureery, either attempted definitive removal or biopsy only. Recent refinements in pathologicalevaluation of these tumours are discussed. Seven cases were deemed classical olfactory neuroblastoma whilst two were classified as neuroendocrine carcinoma. The clinical features, radirap technique and variable natural history are presented. Seven of eight patients treatecall were controlled locally, with a minimumfollow-up of two years. Three patients developedcervica lymph node disease and three patients died of systemic metastatic disease. Suggestios are made as to which patients should have en-bloc resection rather than definitive radiotherapy.

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Corresponding author

Address for correspondence: Dr N. J. Slevin, Consultant Radiotherapist and Oncologist, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX Fax: 0161-446-3352

References

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Anavi, Y., Bahar, M., Ben-Bassat, M. (1989) Report of a case and review of the literatul factory neuroblastoma. Journal of Oral Maxillofacial Surgery 47: 514517.
Biller, H. F., Lawson, W., Sachdev, V. P., Som, P. (1990) Esthesioneuroblastoma: surgical treatment without radiation. Laryngoscope 100: 11991201.
Canty, P. (1979) Olfactory neuroblastoma: long term survival. Journal of Laryngology and Otology 93: 285292.
Chapman, P., Carter, R. L., Clifford, P. (1981) The diagnosisand surgical management of olfactory neuroblastoma: The role of craniofacial resection. Journal of Laryngology and Otology 95: 785799.
Daly, N. J., Voigt, J. J., Combes, P. F. (1980) Diagnosis and treatment of olfactory neuroblastomas in seven patients. International Journal of Radiation Oncology, Biology and Physics 6: 17351738.
Kadish, S., Goodman, M., Wang, C. C. (1976) A clinical analysis of 17 cases, olfactory neuroblastoma. Cancer 37: 15711576.
Levine, P. A., McLean, W. C., Cantrell, R. W. (1986) Esthesioneuroblastoma: The University of Virginia Experience 1960–1985. Laryngoscope 96: 742746.
Logue, J. P., Banerjee, S. S., Slevin, N. J., Vasanthan, S. (1991) Neuroendocrine carcinomas of the larynx. Journal of Laryngology and Otology 105: 10311035.
Michaels, L. (1989) Head and Neck Tumours. Chap. 6 Recent advances in histopathology, no 14 (Anthony, P. P., MacSween, R. N. M., ed.) Churchill Livingstone, Edinburgh, pp 107112.
Morita, A., Ebersold, M. J., Olsen, K. D., Foote, R. L., Lewis, J. E., Quast, L. M. (1993) Esthesioneuroblastoma: prognosis and management. Neurosurgery 32: 706715.
Ordonez, N. G., Mackay, B. (1993) Neuroendocrine tumours of the nasal cavity. In Pathology Annual 2 (Rosen, P. P., Fechner, R. E., ed.) Appleton and Lange, Norwalk (Conn.) pp 77113.
O'Connor, T. A., McLean, P., Juillard, G. J. F., Parker, R. G. (1989) Olfactory neuroblastoma. Cancer 63: 24262428.
Pape, H., Wurm, R., Schmitt, G. (1990) Pathogenese und Klinik der Ästhesioneuroblastome, Literaturüberblick und Analyse von 235 Fällen. Tumoriagnostik und Therapie 11: 237242.
Parsons, J. T., Mendenhall, W. M., Mancuso, A. A., Cassisi, N. J., Million, R. R. (1988) Malignant tumors of the nasal cavity and ethmoid and sphenoid sinuses. International Journal of Radiation Oncology, Biology and Physics 14: 1122.
Sakata, K. -I., Aoki, Y., Karasawa, K., Nakagawa, K., Hasezawa, K., Muta, N., Terahara, A., Onogi, Y., Sasaki, Y., Akanuma, A., Mohri, N. (1993) Esthesioneuroblastoma, A report of seven cases. Acta Oncologica 32: 399–302.
Silva, E. G., Butler, J. J., Mackay, B., Goepfert, H. (1982) Neuroblastomas and neuroendocrine carcinomas of the nasal cavity, a proposed new classification. Cancer 50: 23882405.
Urdaneta, N., Fischer, J. J., Knowlton, A. (1988) Olfactory neuroblastoma, observations on seven patients treated with adiation therapy and review of the literature. American ournal of Clinical Oncology 11: 672678.

Keywords

Olfactory neural tumours—the role of external beam radiotherapy

  • N. J. Slevin (a1), C. J. R. Irwin (a1), S. S. Banerjee (a2), N. K. Gupta (a1) and W. T. Farrington (a3)...

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