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New inflammatory parameters in laryngopharyngeal reflux

  • H Arslan (a1), T Çandar (a2), S Kuran (a3), Ş H Akmansu (a1) and S Kocatürk (a1)...

Abstract

Objectives:

To investigate new inflammatory markers in patients with laryngopharyngeal reflux and determine whether these inflammatory parameters change in response to laryngopharyngeal reflux treatment.

Methods:

Complete blood count was evaluated to obtain platelet count and mean platelet volume and calculate neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Laryngopharyngeal reflux patients underwent three-month lansoprazole treatment.

Results:

The study included 45 laryngopharyngeal reflux patients (9 men (20 per cent); mean age, 37.4 ± 11.6 years) and 35 healthy age- and sex-matched controls (7 men (20 per cent); mean age, 38.6 ± 8.9 years). The study group had significantly higher platelet-to-lymphocyte ratios and lower mean platelet volumes than the control group (p = 0.004 and p = 0.047, respectively). There was a significant correlation between platelet-to-lymphocyte ratios and initial inflammatory symptoms (reflux symptom index, p = 0.025; reflux finding score, p = 0.013). There was also a significant correlation between mean platelet volume increase and symptom resolution in the first and third months of treatment (p = 0.04 and p = 0.03, respectively).

Conclusion:

Platelet-to-lymphocyte ratio, a new inflammatory marker of chronic inflammation, was significantly higher in laryngopharyngeal reflux patients. Moreover, these patients had significantly lower mean platelet volume values, which increased with post-treatment symptom improvement.

Copyright

Corresponding author

Address for correspondence: Dr Hande Arslan, Department of Otorhinolaryngology, Ufuk University Medical School, Balgat 06520, Ankara, Turkey E-mail: handearslan5@yahoo.com

References

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Keywords

New inflammatory parameters in laryngopharyngeal reflux

  • H Arslan (a1), T Çandar (a2), S Kuran (a3), Ş H Akmansu (a1) and S Kocatürk (a1)...

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