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Naproxen in otitis media with effusion

Published online by Cambridge University Press:  29 June 2007

S. Abramovich ,
J. O'Grady ,
A. Fuller ,
M. MacKinnon  and
R. Lavelle
S. Abramovich
Affiliation:
London
J. O'Grady*
Affiliation:
London ENT Department and Department of Clinical Pharmacology, St. Bartholonew's Hospital, London.
A. Fuller
Affiliation:
London
M. MacKinnon
Affiliation:
London
R. Lavelle
Affiliation:
London
*
J. O'Grady, MD, MRCP, Department of Clinical Pharmacology, The Clinical Research Division, The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS.
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Abstract

The levels of prostaglandian E2 (PGE2) were measured in aspirates of the effusion fluid from children suffering from secretory otitis media. The effects of naproxen 5 mg./kg. twice daily for eight weeks on the condition were studied in a placebocontrolled double-blind trial.

Nineteen middle-ear aspiraes from 13 children, six of whom had bilateral aspirations were examined. Detectable levels of PGE2 and those without.

In a separate trial of naproxen, 11 patients received active drug and 13 received placebo. Naproxen had no significant effect on otalgia or hearing loss compared to placedo.

These findings suggest that is it unlikely that non-steroidal anti-inflammatory drug will be of therapeutic benefit in secretory otitis media.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 3 , March 1986 , pp. 263 - 266
Copyright
Copyright © JLO (1984) Limited 1986

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References

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