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Micro-ribonucleic acids in head and neck cancer: an introduction

  • I Gunawardena (a1), J Fitzgerald (a1), A Morley (a1), D J Hussey (a2), C M Woods (a1) and A S Carney (a1)...

Abstract

Background and methods:

Head and neck cancer is the sixth most common cancer worldwide. Advances in management have not greatly altered overall survival. Over the last decade, there have been significant scientific advances in our knowledge of cell cycle regulation and the complex oncogenic processes. MicroRNAs are small, non-coding RNAs which are integral to the regulation of gene expression and which play a part in carcinogenesis. The literature on the role of microRNA in head and neck cancer is reviewed.

Objective:

To introduce the role and significance of microRNAs in head and neck cancer.

Results:

The possibilities of incorporating microRNAs into clinical practice are discussed, including their potential role in diagnosis, prognosis, prediction of metastatic spread, therapy and tumour surveillance.

Conclusion:

Discoveries in expression profiling of microRNA in head and neck oncology promise advancements in the diagnosis, prognosis and therapy of these cancers.

Copyright

Corresponding author

Address for correspondence: Dr I Gunawardena, Flinders ENT, Department of Surgery, Flinders Medical Centre and Flinders University, Bedford Park, SA, Australia 5042 Fax: (+618) 82199908 E-mail: indunilg@hotmail.com

References

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1Jemal, A, Siegel, R, Ward, E, Hao, Y, Xu, J, Murray, T et al. Cancer statistics. CA Cancer J Clin 2008;58:7196
2Bonner, JA, Harari, PM, Giralt, J, Azarnia, N, Shin, DM, Cohen, RB et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567–78
3Babu, JM, Prathibha, R, Jijith, VS, Hariharan, R, Pillai, MR. A miR-centric view of head and neck cancers. Biochim Biophys Acta 2011;1816:6772
4Calin, GA. MicroRNAs and cancer: what we know and what we still have to learn. Genome Med 2009;1:78
5Kim, VN, Nam, JW. Genomics of microRNA. Trends Genet 2006;22:165–73
6Kim, VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005;6:376–85
7Kim, VN, Han, J, Siomi, MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009;10:126–39
8Gantier, MP, Sadler, AJ, Williams, BR. Fine-tuning of the innate immune response by microRNAs. Immunol Cell Biol 2007;85:458–62
9Xiao, C, Rajewsky, K. MicroRNA control in the immune system: basic principles. Cell 2009;136:2636
10O'Connell, RM, Rao, DS, Chaudhuri, AA, Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111–22
11Ramdas, L, Giri, U, Ashorn, CL, Coombes, KR, El-Naggar, A, Ang, KK et al. miRNA expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue. Head Neck 2009;31:642–54
12Sulston, JE, Brenner, S. The DNA of Caenorhabditis elegans. Genetics 1974;77:95104
13Brenner, S. The genetics of Caenorhabditis elegans. Genetics 1974;77:7194
14Lee, RC, Feinbaum, RL, Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843–54
15Wightman, B, Ha, I, Ruvkun, G, Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993;75:855–62
16miRBase: the microRNA data base. In: http://miRBASE.org [18 November 2011]
17Rodriguez, A, Griffiths-Jones, S, Ashurst, JL, Bradley, A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004;14:1902–10
18Gregory, RI, Yan, KP, Amuthan, G, Chendrimada, T, Doratotaj, B, Cooch, N et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004;432:235–40
19Carthew, RW, Sontheimer, EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009;136:642–55
20Gomes, CC, Gomez, RS. MicroRNA and oral cancer: future perspectives. Oral Oncol 2008;44:910–14
21Lu, J, Getz, G, Miska, EA, Alvarez-Saavedra, E, Lamb, J, Peck, D et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834–8
22Chen, HC, Chen, GH, Chen, YH, Liao, WL, Liu, CY, Chang, KP et al. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 2009;100:1002–11
23Calin, GA, Dumitru, CD, Shimizu, M, Bichi, R, Zupo, S, Noch, E et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002;99:15524–9
24Jiang, J, Lee, EJ, Gusev, Y, Schmittgen, TD. Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 2005;33:5394–403
25Chang, SS, Jiang, WW, Smith, I, Poeta, LM, Begum, S, Glazer, C et al. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 2008;123:2791–7
26Childs, G, Fazzari, M, Kung, G, Kawachi, N, Brandwein-Gensler, M, McLemore, M et al. Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Am J Pathol 2009;174:736–45
27Tran, N, McLean, T, Zhang, X, Zhao, CJ, Thomson, JM, O'Brien, C et al. MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007;358:1217
28Fletcher, AM, Heaford, AC, Trask, DK. Detection of metastatic head and neck squamous cell carcinoma using the relative expression of tissue-specific mir-205. Transl Oncol 2008;1:202–8
29Jakymiw, A, Patel, RS, Deming, N, Bhattacharyya, I, Shah, P, Lamont, RJ et al. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer 2010;49:549–59
30Wong, TS, Ho, WK, Chan, JY, Ng, RW, Wei, WI. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008;14:2588–92
31Avissar, M, McClean, MD, Kelsey, KY, Marsit, CJ. MicroRNA expression in head and neck cancer associates with alcohol consumption and survival. Carcinogenesis 2009;30:2059–63
32Hui, AB, Lenarduzzi, M, Krushel, T, Waldron, L, Pintilie, M, Shi, W et al. Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res 2010;16:1129–39
33Avissar, M, Christensen, BC, Kelsey, KY, Marsit, CJ. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res 2009;15:2850–5
34Henson, BJ, Bhattacharjee, S, O'Dee, DM, Feingold, E, Gollin, SM. Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer 2009;48:569–82
35Long, XB, Sun, GB, Hu, S, Liang, GT, Wang, N, Zhang, XH et al. Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. Oncol Rep 2009;22:1189–95
36Barker, EV, Cervigne, NK, Reis, PP, Goswami, RS, Xu, W, Weinreb, I et al. MicroRNA evaluation of unknown primary lesions in the head and neck. Mol Cancer 2009;23:127
37Liu, X, Wang, C, Chen, Z, Jin, Y, Wang, Y, Kolokythas, A et al. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J 2011;440:2331
38Jiang, L, Dai, Y, Liu, X, Wang, C, Wang, A, Chen, Z et al. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet 2011;129:189–97
39Hurst, DR, Edmonds, MD, Welch, DR. Metastamir: the field of metastasis-regulatory microRNA is spreading. Cancer Res 2009;69:7495–8
40HeNeCan miRs – A database of integrative information on head and neck cancer associated microRNAs. http://tarmir.rgcb.res.in/henecan [19 April 2012]
41Park, NJ, Zhou, H, Elashoff, D, Henson, BS, Kastratovic, DA, Abemayor, E et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res 2009;15:5473–7
42Liu, CJ, Kao, SY, Tu, HF, Tsai, MM, Chang, KW, Lin, SC. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Dis 2010;16:360–4
43Wong, TS, Ho, WK, Chan, JY, Ng, RW, Wei, WI. Mature miR-184 and squamous cell carcinoma of the tongue. Scientific World Journal 2009;9:130–2
44Bader, AG, Brown, D, Winkler, M. The promise of microRNA replacement therapy. Cancer Res 2010;70:7027–30
45Krutzfeldt, J, Rajewsky, N, Braich, R, Rajeev, KG, Tuschi, T, Manoharan, M et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature 2005;438:685–9
46Ebert, MS, Neilson, JR, Sharp, PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007;4:721–6
47MacDiarmid, JA, Madrid-Weiss, J, Amaro-Mugridge, NB, Phillips, L, Brahmbhatt, H. Bacterially-derived nanocells for tumor-targeted delivery of chemotherapeutics and cell cycle inhibitors. Cell Cycle 2007;6:2099–105

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