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Measuring nasal nitric oxide in allergic rhinitis patients

Published online by Cambridge University Press:  08 November 2016

V S Nesic ,
V Z Djordjevic ,
V Tomic-Spiric ,
Z R Dudvarski ,
I A Soldatovic  and
N A Arsovic
V S Nesic*
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia
V Z Djordjevic
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia
V Tomic-Spiric
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia Clinic of Allergology and Immunology, Clinical Centre of Serbia, Belgrade, Serbia
Z R Dudvarski
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia
I A Soldatovic
Affiliation:
Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, Belgrade, Serbia
N A Arsovic
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia
*
Address for correspondence: Dr V S Nesic, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia. E-mail: snesic@sbb.rs
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Abstract

Objective:

This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement.

Methods:

The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide).

Results:

Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability.

Conclusion:

Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting.

Keywords

Nitric OxideNoseReproducibility of ResultsRhinitisAllergicPerennial
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 11 , November 2016 , pp. 1064 - 1071
Copyright
Copyright © JLO (1984) Limited 2016 

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