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Measuring nasal nitric oxide in allergic rhinitis patients

  • V S Nesic (a1) (a2), V Z Djordjevic (a1) (a2), V Tomic-Spiric (a1) (a3), Z R Dudvarski (a1) (a2), I A Soldatovic (a4) and N A Arsovic (a1) (a2)...

Abstract

Objective:

This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement.

Methods:

The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose. Nasal nitric oxide was measured by two different methods: (1) nasal aspiration via one nostril during breath holding and (2) single-breath quiet exhalation against resistance through a tight facemask (i.e. the nasal fractional exhaled nitric oxide).

Results:

Compared with healthy participants, allergic rhinitis patients had significantly higher average oral and nasal nitric oxide levels. All methods of nitric oxide measurement had excellent reliability.

Conclusion:

Nasal nitric oxide measurement is a useful and reliable clinical tool for diagnosing allergic rhinitis in patients without asthma in an out-patient setting.

Copyright

Corresponding author

Address for correspondence: Dr V S Nesic, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia. E-mail: snesic@sbb.rs

References

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Keywords

Measuring nasal nitric oxide in allergic rhinitis patients

  • V S Nesic (a1) (a2), V Z Djordjevic (a1) (a2), V Tomic-Spiric (a1) (a3), Z R Dudvarski (a1) (a2), I A Soldatovic (a4) and N A Arsovic (a1) (a2)...

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