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Malignant myoepithelioma of the parotid gland: case report and review of the literature

Published online by Cambridge University Press:  29 June 2007

Thomas R. Klumpp ,
Rose M. Mohr ,
Craig L. Silverman ,
Chik-Kwun Tang ,
I. B. Elfenbein  and
Irving Dardick
Thomas R. Klumpp*
Affiliation:
Temple University Comprehensive Cancer Center and the Departments of Medicine.
Rose M. Mohr
Affiliation:
Otorhinolaryngology and Bronchoesophagology, Temple University School of Medicine, Philadelphia, P.A.
Craig L. Silverman
Affiliation:
Radiation Oncology, Temple University School of Medicine, Philadelphia, P.A.
Chik-Kwun Tang
Affiliation:
Pathology, Temple University School of Medicine, Philadelphia, P.A.
I. B. Elfenbein
Affiliation:
Pathology, Temple University School of Medicine, Philadelphia, P.A.
Irving Dardick
Affiliation:
Department of Pathology, University of Toronto, Toronto, Ontario, Canada.
*
Dr Thomas R. Klumpp, Assistant Director, Bone Marrow Transplant Program, Temple University Comprehensive Cancer Center, P.O. Box 38346, 3322 North Broad Street, Philadelphia, PA 19140, USA. Fax: 215-707-2746
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Abstract

A 62-year-old male with a myoepithelioma of the right parotid gland was treated with surgical excision followed by adjuvant radiation therapy. Prior to the completion of radiation therapy, the patient developed progressive disease at local, regional, and distant metastatic sites. Combined modality treatment with radiation and chemotherapy resulted in a significant but transient shrinkage of the tumours at all sites. The patient succumbed to metastatic disease 212 days following the diagnostic biopsy. This case illustrates several of the distinctive clinical and pathological characteristics of this rare tumour.

Keywords

Head and neck neoplasmsParotid glandMyoepithelioma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 10 , October 1995 , pp. 995 - 998
Copyright
Copyright © JLO (1984) Limited 1995

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References

Barnes, L., Appel, B. N., Perez, H., El-Attar, A. M. (1985) Myoepitheliomas of the head and neck: case report and review. Journal of Surgical Oncology 28: 28–21.CrossRefGoogle ScholarPubMed
Batsakis, J. G., Kraemer, B., Sciubba, J. J. (1983) The pathology of head and neck tumors: the myoepithelial cell and its participation in salivary gland neoplasia, part 17. Head and Neck Surgery 5: 5–222.CrossRefGoogle ScholarPubMed
Batsakis, J. G. (1985) Editorial Note. Head and Neck Surgery 7: 394.CrossRefGoogle Scholar
Batsakis, J. G., Ordonez, N. G., Ro, J., Meis, J. M., Bruner, J. M. (1986) S-100 protein and myoepithelial neoplasms. Journal of Laryngology and Otology 100: 100–687.CrossRefGoogle ScholarPubMed
Crissman, J. D., Wirman, J. A., Harris, A. (1977) Malignant myoepithelioma of the parotid gland. Cancer 40: 40–3042.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Dardick, I., van Nostrand, A. W. P., Phillips, M. J. (1982) Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cell. Human Pathology 13: 13–62.CrossRefGoogle ScholarPubMed
Dardick, I. (1985) Malignant myoepithelioma of parotid salivary gland. Ultrastructural Pathology 9: 9–163.CrossRefGoogle ScholarPubMed
Dardick, I., van Nostrand, A. W. P. (1987) Morphogenesis of salivary gland tumors. A prerequisite to improving classification. Pathology Annual 1: 1–1.Google Scholar
Dardick, I., Thomas, M. J., van Nostrand, A. W. P. (1989a) Myoepithelioma - new concepts of histology and classification: a light and electron microscopic study. Ultrastructural Pathology 13: 13–187.CrossRefGoogle ScholarPubMed
Dardick, I., Cavell, S., Boivin, M., Hoppe, D., Parks, W. R., Stinson, J., Yamada, S., Burns, B. F. (1989b) Salivary gland myoepithelioma variants. Histological, ultrastructural, and immunocytological features. Virchows Archiv [A] Pathological Anatomy and Histopathlogy 416: 416–25.Google ScholarPubMed
Dardick, I., Stratis, M., Parks, W. R., DeNardi, F. G., Kahn, H. J. (1991) S-100 protein antibodies do not label normal salivary gland myoepithelium. American Journal of Pathology 138: 138–619.Google Scholar
Dardick, I., Ostrynski, V. L., Ekem, J. K., Leung, R., Burford-Mason, A. P. (1992) Immunohistochemical and ultrastructural correlates of muscle-actin expression in pleomorphic adenomas and myoepitheliomas based on comparison of formalin and methanol fixation. Virchows Archiv [A] Pathological Anatomy and Histopathology 421: 421–95.Google ScholarPubMed
Dardick, I., Burford-Mason, A. P. (1994) Pathology of the salivary glands: the contribution of electron microscopy. Microscopy Research and Technique 27: 27–46.CrossRefGoogle ScholarPubMed
DiPalma, S., Pilotti, S., Rilke, F. (1991) Malignant myoepithelioma of the parotid gland arising in a pleomorphic adenoma. Histopathology 19: 19–273.Google Scholar
DiPalma, S., Guzzo, M. (1993) Malignant myoepithelioma of salivary glands – clinicopathological features of ten cases. Virchows Archiv [A] Pathological Anatomy and Histopathology 423: 423–389.Google Scholar
El-Naggar, A., Batsakis, J. G., Luna, M. A., Goepfert, H., Tortoledo, M. E. (1989) DNA content and proliferative activity of myoepitheliomas. Journal of Laryngology and Otology 103: 103–1192.CrossRefGoogle ScholarPubMed
Franke, W. W., Schmid, E., Freudenstein, C., Appelhans, B., Osborn, M., Weber, K., Keenan, T. W. (1980) Intermediate-sized filaments of the prekeratin type in myoepithelial cells. Journal of Cell Biology 84: 84–633.Google ScholarPubMed
Ibrahim, R., Bird, D. J., Sieler, M. W. (1991) Malignant myoepthelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunochemical study. Ultrastructural Pathology 15: 15–69.CrossRefGoogle Scholar
Mori, M., Tsukitani, K., Ninomiya, T., Okada, Y. (1987) Various expressions of modified myoepithelial cells in salivary pleomorphic adenoma. Immunohistochemical studies. Pathology Research and Practice 182: 182–632.Google ScholarPubMed
Redman, R. S. (1994) Myoepithelium of salivary glands. Microscopy Research and Technique 27: 27–25.CrossRefGoogle ScholarPubMed
Sciubba, J. J., Brannon, R. B. (1982) Myoepithelioma of salivary glands: report of 23 cases. Cancer 49: 49–562.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Sheldon, W. H. (1943) So-called mixed tumors of the salivary glands. Archives of Pathology 35: 35–1.Google Scholar
Singh, R., Cawson, R. A. (1988) Malignant myoepithelial carcinoma (myoepithelioma) arising in a pleomorphic adenoma of the parotid gland. Oral Surgery, Oral Medicine, Oral Pathology 66: 66–65.CrossRefGoogle Scholar
Stromeyer, F. W., Haggitt, R. C., Nelson, J. F., Hardman, J. M. (1975) Myoepithelioma of minor salivary gland origin. Light and electron microscopical study. Archives of Pathology 99: 99–242.Google ScholarPubMed
Tanimura, A., Nakamura, Y., Nagayama, K., Tanaka, S., Hachisuka, H. (1985) Myoepithelioma of the parotid gland. Report of two cases with immunohistochemical technique for S-100 protein and electron microscopic observation. Acta Pathologica Japonica 35: 35–409.CrossRefGoogle ScholarPubMed
Takeda, Y. (1992) Malignant myoepithelioma of minor salivary gland origin. Acta Pathologica Japonica 42: 42–518.CrossRefGoogle ScholarPubMed
Toto, P. D., Hsu, D-J. (1986) Product definition in a case of myoepithelioma. Oral Surgery, Oral Medicine, Oral Pathology 62: 62–169.CrossRefGoogle Scholar