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Kimura's disease: clinicopathological study of eight cases

Published online by Cambridge University Press:  08 January 2013

R P S Punia ,
R Aulakh ,
S Garg ,
R Chopra ,
H Mohan  and
A Dalal
R P S Punia*
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
R Aulakh
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
S Garg
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
R Chopra
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
H Mohan
Affiliation:
Department of Pathology, Government Medical College and Hospital, Chandigarh, India
A Dalal
Affiliation:
Department of General Surgery, Government Medical College and Hospital, Chandigarh, India
*
Address for correspondence: Dr R P S Punia, Department of Pathology, Government Medical College and Hospital, Sector 32, Chandigarh-160030, India Fax: +91 172 266 5375 E-mail: drpunia@gmail.com
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Abstract

Background:

Kimura's disease is a rare, localised, chronic inflammatory disease. This benign disease involves subcutaneous tissues, the major salivary gland, and lymph nodes primarily in the head and neck area.

Method:

Clinical details and stained slides of all cases reported as Kimura's disease over a 10-year period were reviewed.

Results:

There were eight cases of Kimura's disease. The mean age of patients was 22.8 years. One case showed associated nephrotic syndrome and two cases were associated with peripheral blood eosinophilia. All cases showed the typical histopathological features of Kimura's disease.

Conclusion:

Kimura's disease was first reported in China in 1937. The cause of Kimura's disease is unknown and many theories have been proposed. The eight cases reported here illustrate some of the variations in the mode of presentation and in the histological features of Kimura's disease. Kimura's disease should be considered in the differential diagnosis of patients who present with head and neck swellings and lymphadenopathy, and investigated accordingly.

Keywords

Kimura DiseaseNeckLymphadenopathyNephrotic SyndromeAngiolymphoid Hyperplasia With Eosinophilia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 2 , February 2013 , pp. 170 - 174
Copyright
Copyright © JLO (1984) Limited 2013

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