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Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?

  • O Ismi (a1), T Kara (a2), G Polat (a3), O Bobusoglu (a3), Y Vayısoglu (a1), K Gorur (a1) and C Ozcan (a1)...



Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.


The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.


Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund–Mackay scores (p = 0.792).


Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.


Corresponding author

Author for correspondence: Dr Onur Ismi, Mersin Üniversitesi Tıp Fakültesi Hastanesi, Kulak Burun Boğaz AD, Çiftlikköy Kampüsü, Çiftlikköy/Yenişehir, Mersin, Turkey Fax: +90 3242 380 091 E-mail:


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Dr O Ismi takes responsibility for the integrity of the content of the paper



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1Pawankar, R. Nasal polyposis: an update. Curr Opin Allergy Clin Immunol 2003;3:16
2Pawankar, R, Nonaka, M. Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep 2007;7:202–8
3Coffey, CS, Mulligan, RM, Schlosser, RJ. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. Am J Rhinol Allergy 2009;23:571–4
4Terzakis, D, Georgalas, C. Polyps, asthma and allergy: what's new. Curr Opin Otolaryngol Head Neck Surg 2017;25:1218
5Li, QC, Cheng, KJ, Wang, F, Zhou, SH. Role of atopy in chronic rhinosinusitis with nasal polyps: does an atopic condition affect the severity and recurrence of disease? J Laryngol Otol 2016;130:640–4
6Aversa, S, Ondolo, C, Abbadessa, G, Piccione, F, Carriero, V, Fulcheri, A et al. Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-1β. Rhinology 2012;50:427–35
7Ozcan, C, Tamer, L, Ates, NA, Gorur, K. The glutathione-s-transferase gene polymorphisms (Gstt1, Gstm1, and Gstp1) in patients with non-allergic nasal polyposis. Eur Arch Otorhinolaryngol 2010;267:227–32
8Nockher, WA, Renz, H. Neurotrophins and asthma: novel insight into neuroimmune interaction. J Allergy Clin Immunol 2006;117:6771
9Jornot, L, Grouzmann, E, Lacroix, JS, Rochat, T. BDNF and DPP-IV in polyps and middle turbinates epithelial cells. Rhinology 2007;45:129–33
10Ismi, O, Ozcan, C, Karabacak, T, Polat, G, Vayisoglu, Y, Gucluturk, T et al. Local effect of neurotrophin-3 in neuronal inflammation of allergic rhinitis: preliminary report. Balkan Med J 2015;32:364–70
11Raap, U, Fokkens, W, Bruder, M, Hoogsteden, H, Kapp, A, Braunstahl, GJ. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy 2008;63:468–75
12Gelincik, A, Aydin, F, Ozerman, B, Erguven, M, Aydın, S, Bilir, A et al. Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis. Ann Allergy Asthma Immunol 2012;108:396401
13Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:112
14Bateman, ED, Hurd, SS, Barnes, PJ, Bousquet, J, Drazen, JM, FitzGerald, M et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143–78
15Lund, VJ, Mackay, IS. Staging in rhinosinusitis. Rhinology 1993;31:183–4
16Barcena de Arellano, ML, Wagner, MF, Oldeweme, J, Arnold, J, Ebert, A, Schneider, A et al. Neurotrophin expression is not affected in uteri of women with adenomyosis. J Mol Neurosci 2012;47:495504
17Ozcan, C, Zeren, H, Talas, DU, Kucukoglu, M, Gorur, K. Antrochoanal polyp: a transmission electron and light microscopic study. Eur Arch Otorhinolaryngol 2005;262:5560
18Dennis, SK, Lam, K, Luong, A. A review of classification schemes for chronic rhinosinusitis with nasal polyposis endotypes. Laryngoscope Investig Otolaryngol 2016;1:130–4
19Raap, U, Braunstahl, GJ. The role of neurotrophins in the pathophysiology of allergic rhinitis. Curr Opin Allergy Clin Immunol 2010;10:813
20Manti, S, Brown, P, Perez, MK, Piedimonte, G. The role of neurotrophins in inflammation and allergy. Vitam Horm 2017;104:313–41
21Noga, O, Englmann, C, Hanf, G, Grützkau, A, Seybold, J, Kunkel, G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy 2003;33:649–54
22Kobayashi, H, Gleich, GJ, Butterfield, JH, Kita, H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood 2002;99:2214–20
23Wu, X, Myers, AC, Goldstone, AC, Togias, A, Sanico, AM. Localization of nerve growth factor and its receptors in the human nasal mucosa. J Allergy Clin Immunol 2006;118:428–33
24Beatrice, F, Aluffi, P, Bottomicca, F, Perlasco, L, Sartoris, A. Nasal polyps and substance P: a preliminary report [in Italian]. Acta Otorhinolaryngol Ital 1994;14(suppl 41):35–9
25Gungor, A, Baroody, FM, Naclerio, RM, White, SR, Corey, JP. Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps. Otolaryngol Head Neck Surg 1999;121:585–90



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