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Intratympanic gentamicin treatment for unilateral Ménière's disease: long-term follow up of a proven regime

Published online by Cambridge University Press:  07 December 2012

J Wasson ,
N Upile  and
A Pfleiderer
J Wasson*
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital, UK
N Upile
Affiliation:
Department of Otolaryngology, Peterborough City Hospital, UK
A Pfleiderer
Affiliation:
Department of Otolaryngology, Peterborough City Hospital, UK
*
Address for correspondence: Mr J Wasson, 80 Tenison Rd, Cambridge CB1 2DW, UK E-mail: josephwasson@hotmail.com
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Abstract

Objective:

To determine the long-term efficacy of a fixed-dose intratympanic gentamicin treatment regime in controlling unilateral Ménière's disease.

Methods:

Pfleiderer (1998) published two-year follow-up results for a series of 16 patients treated with a 4-day, 12-dose intratympanic gentamicin regime for unilateral Ménière's disease that was refractory to medical treatment. In 2010, a long-term telephone follow up (mean 17 years and 3 months) of this same cohort was conducted to determine long-term vertigo control. Of the 16 patients, 13 were eligible for the long-term follow up.

Results:

At 2 years' follow up, all 16 patients experienced substantial control of vertigo, with complete control achieved in 87 per cent of cases. At the long-term follow up, 9 of the 13 eligible patients were contactable, and all reported complete control of vertigo.

Conclusion:

Fixed-dose intratympanic gentamicin controlled symptomatic unilateral Ménière's disease in both the short and long term.

Keywords

Ménière's diseaseVertigoPostural BalanceGentamicinTherapeuticsFollow-up Studies
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 20 - 24
Copyright
Copyright © JLO (1984) Limited 2012

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References

1 Schuknecht, HF. Ablation therapy in the management of Menière's disease. Acta Otolaryngol Suppl 1957;132:1–42 Google ScholarPubMed
2 Chia, SH, Gamst, AC, Anderson, JP, Harris, JP. Intratympanic gentamicin therapy for Ménière's disease: a meta-analysis. Otol Neurotol 2004;25:544–52CrossRefGoogle ScholarPubMed
3 Smith, WK, Sankar, V, Pfleiderer, AG. A national survey amongst UK otolaryngologists regarding the treatment of Ménière's disease. J Laryngol Otol 2005;119:102–5CrossRefGoogle ScholarPubMed
4 Nedzelski, JM, Schessel, DA, Bryce, GE, Pfleiderer, AG. Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Menière's disease. Am J Otol 1992;13:18–22 Google ScholarPubMed
5 Bodmer, D, Morong, S, Stewart, C, Alexander, A, Chen, JM, Nedzelski, JM. Long-term vertigo control in patients after intratympanic gentamicin instillation for Ménière's disease. Otol Neurotol 2007;28:1140–4CrossRefGoogle ScholarPubMed
6 Pfleiderer, AG. The current role of local intratympanic gentamicin therapy in the management of unilateral Menière's disease. Clin Otolaryngol Allied Sci 1998;23:34–41 CrossRefGoogle ScholarPubMed
7 Alford, BR. Committee on Hearing and Equilibrium. Report of Subcommittee on Equilibrium and its Measurement: Meniere's disease: criteria for diagnosis and evaluation of therapy for reporting. Trans Am Acad Ophthalmol Otolaryngol 1972;76:1462–4Google Scholar
8 Cohen-Kerem, R, Kisilevsky, V, Einarson, TR, Kozer, E, Koren, G, Rutka, JA. Intratympanic gentamicin for Menière's disease: a meta-analysis. Laryngoscope 2004;114:2085–91CrossRefGoogle ScholarPubMed
9 Beck, C. Intratympanic application of gentamicin for treatment of Menière's disease. Keio J Med 1986;35:36–41 CrossRefGoogle ScholarPubMed
10 Hone, WS, Nedzelski, J, Chen, J. Does intratympanic gentamicin treatment for Meniere's disease cause complete vestibular ablation? J Otolaryngol 2000;29:83–7Google ScholarPubMed