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Internal jugular vein thrombosis in association with the factor V Leiden mutation

  • P. Arullendran (a1), P. Jani (a1), T. Baglin (a2) and D. A. Moffat (a1)

Abstract

We report an unusual case of internal jugular vein thrombosis in a 57-year-old female, with the recently discovered factor V Leiden (FVR506Q) mutation. The molecular basis of this mutation is described, and the importance of screening for hereditary venous thrombotic states is emphasized.

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Corresponding author

Address for correspondence: Mr P. Arullendran, Specialist Registrar, ENT Department, Sunderland Royal Hospital, Sunderland SR4 7TP.

References

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Beauchamp, N., Daly, M., Hampton, K., Cooper, P., Preston, F., Peake, I. (1994) High prevalence of a mutation in the factor V gene within the UK population: Relationship to activated protein C resistance and familial thrombosis. British Journal of Haematology 88: 219222.
Bertina, R., Koeleman, B., Koster, T., Rosendaal, F., Dirven, R., de Ronde, H., van der Velden, P., Reitsma, P. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369: 6467.
Dahlback, B., Carlsson, M., Svensson, P. (1993) Familial thrombophilia due to unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C: Leiden thrombophilia study. Proceedings of the National Academy of Sciences of the United States of America 90: 10041008.
Horstkamp, B., Lubke, M., Kentenich, H., Reiss, H., Buscher, U., Lichtenegger, W. (1996) Internal jugular vein thrombosis caused by resistance to activated protein C as a compilation of ovarian hyperstimulation after in vitro fertilization. Human Reproduction 11(2): 280282.
Jorquera, J., Montoro, J., Fernandez, M., Azaner, J. A., Azaner, J. (1994) Modified test for activated protein C resistance. Lancet 344: 11621163.
Rosendaal, F., Koster, T., Vandenbrouck, J., Reitsma, P. (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85: 15041508.
Wilde, J. T. (1995) The investigation of a patient with unexpected venous thrombosis. Postgraduate Medical Journal 71: 720724.

Keywords

Internal jugular vein thrombosis in association with the factor V Leiden mutation

  • P. Arullendran (a1), P. Jani (a1), T. Baglin (a2) and D. A. Moffat (a1)

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